Cinaciguat ( —— )

产品货号. M14089 CAS No. 329773-35-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Cinaciguat
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Cinaciguat (BAY 58-2667) 是临床开发中第一种新型可溶性鸟苷酸环化酶 (sGC) 激活剂，用于治疗急性失代偿性心力衰竭。
产品描述

Cinaciguat (BAY 58-2667) is the first of a new class of soluble guanylate cyclase (sGC) activators in clinical development for acute decompensated heart failure.(In Vitro):Cinaciguat (10 μM) significantly enhances intracellular cGMP generation. Cinaciguat does not dose-dependent effects on cell contraction and calcium transients.(In Vivo):Cinaciguat (10 mg/kg/day, p.o.) treatment in diabetic rats does not influence blood glucose levels, but leads to attenuated water intake. Cinaciguat treatment alleviates diabetes mellitus related oxidative stress, protects against DM related alteration of the NO-sGC-cGMP-PKG signalling, and alleviates DM related myocardium hypertrophy and apoptosis. Cinaciguat (1-10-100 nM) induces concentration-dependent relaxations in strips from both WT and apo-sGC mice, but does not have any effect on phasic activity induced by PGF2α in WT or apo-sGC strips.
体外实验

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体内实验

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同义词

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通路

Others
靶点

Other Targets
受体

sGC
研究领域

Cardiovascular Disease
适应症

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CAS Number

329773-35-5
分子量

565.7
分子式

C36H39NO5
纯度

>98% (HPLC)
溶解度

DMSO: 10 mM
SMILES

OC(=O)CCCCN(CCC1=CC=CC=C1OCC1=CC=C(CCC2=CC=CC=C2)C=C1)CC1=CC=C(C=C1)C(O)=O
化学全称

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1.Mihai Gheorghiade1, et al. Eur J Heart Fail (2012) 14 (9): 1056-1066.

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