BRD4354

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BRD4354 是一种中等效力、选择性、可逆的 HDAC5 和 HDAC9 抑制剂，IC50 分别为 0.85 uM 和 1.88 uM。

BRD4354 is a moderately potent, selective, reversible inhibitor of HDAC5 and HDAC9 with IC50 of 0.85 uM and 1.88 uM; shows weak activity against HDACs 4, 6, 7, and 8 (IC50=3.88-13.8 uM) and no inhibitory effect on other class I HDACs 1, 2, and 3 (IC50 > 40 uM).

BRD 4354 is a moderately potent inhibitor of HDAC5 and HDAC9, with BRD4354 having half-maximum inhibitory concentrations (IC50) of 0.85 μM and 1.88 μM, respectively. BRD 4354 also inhibits HDACs 4, 6, 7, and 8 at higher concentrations (3.88-13.8 μM) but demonstrates less of an inhibitory effect on other class I HDACs 1, 2, and 3 (IC50>40 μM) .

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BRD 4354

Cell Cycle/DNA Damage

HDAC

HDAC

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315698-07-8

382.892

C21H23ClN4O

>98% (HPLC)

DMSO : 125 mg/mL326.46 mM;

OC1=C2N=CC=CC2=C(Cl)C=C1C(N3CCN(CC)CC3)C4=CC=CN=C4

5-chloro-7-((4-ethylpiperazin-1-yl)(pyridin-3-yl)methyl)quinolin-8-ol

(-20℃)

With Ice Pack

≥ 2 years