PD-118057

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种有效的选择性 hERG 钾通道 (Kv11.1) 激活剂，可将 HEK293 细胞中 10 uM 的峰值尾部 hERG 电流增加 111.1%。

A potent, selective hERG potassium channel (Kv11.1) activator that increases peak tail hERG current of 111.1% at 10 uM in HEK293 cells; does not ot affect the voltage dependence and kinetics of gating parameters, and open conformation of the channel, also shows no major effect on I(Na), I(Ca,L), I(K1), and I(Ks); shortens the action potential duration and QT interval in arterially perfused rabbit ventricular wedge preparation, prevents action potential duration and QT prolongation caused by dofetilide at 3 uM.Heart Arrhythmia Discontinued.

PD-118057 (3 μM and 10 μM) specifically increases hERG current and inhibits action potential duration in guinea pig ventricular muscle in acute isolation of guinea pig cardiomyocytes.PD-118057 (10 μM) reverses the current inhibition induced by Dof and Mox without changing the "hump" shape of IKr current recorded by action potential clamp, and only slightly increases the peak value of the suppressed current.

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PD 118057 | PD118057

Cell Cycle/DNA Damage

Potassium Channel

Potassium Channel

Cardiovascular Disease

Heart Arrhythmia

313674-97-4

386.272

C21H17Cl2NO2

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (258.89 mM)

O=C(O)C1=CC=CC=C1NC2=CC=C(CCC3=CC=C(Cl)C(Cl)=C3)C=C2

2-{4-[2-(3,4-dichloro-phenyl)-ethyl]-phenylamino}-benzoic acid

(-20℃)

With Ice Pack

≥ 2 years