Indacaterol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Indacaterol(Onbrez; Arcapta) 是一种超长效 β-肾上腺素受体激动剂。

Indacaterol(Onbrez; Arcapta) is an ultra-long-acting β-adrenoceptor agonist.

Cell Viability Assay Cell Line:HT1080 cells (constitutively express MMP-9)Concentration:1, 2.5, 5, 10 μM Incubation Time:12 h (pretreat)Result:Significantly suppressed MMP-9 mRNA expression in the 2.5 to 10 μM range.Cell Migration Assay Cell Line:HT1080 cells (constitutively express MMP-9)Concentration:10 μM Incubation Time:6 h (pretreat for 2 h, then incubat with TNF-α for 4 h)Result:Significantly reduced cell migration of fibrosarcoma and inhibited HT1080 cell migration in the zone of wound healing.Western Blot AnalysisCell Line:HT1080 cells Concentration:1, 2.5, 5, 10 μM Incubation Time:2.5 h (pretreat for 2 h, then incubat with TNF-α for 0.5 h)Result:Suppressed TNF-α induced the phosphorylation of IκBα and IKKα/β (the upstream activators of NF-κB).Inhibited TNF-α-induced NF-κB nuclear translocation when at 5 and 10 μM.Suppressed TNF-α-induced MMP-9 enzyme activity and decreased MMP-9 protein levels in a dose-dependent manner in the 2.5 to 10 μM range.

Animal Model:Male Wistar rats (225-250 g; myocardial infarction (MI) rat model of heart failure (HF)).Dosage:0.3 mg/kg Administration:In animal drinking water; sinle daily for 15 weeks Result:Significantly reduced both mean arterial blood pressure and heart rate.Increased both systolic and diastolic LVID where in HF, and reversed the decreased ejection fraction (%) values.Significantly reduced the infarct size, and catecholamine values to basal levels.Significantly increased β1 mRNA expression and cardiac cAMP levels in respect to HF.

QAB149

Endocrinology/Hormones

Adrenergic Receptor

β-adrenoceptor

Neurological Disease

——

312753-06-3

392.49

C24H28N2O3

>98% (HPLC)

DMSO: 10 mM

O=C1NC2=C(C([C@@H](O)CNC3CC4=C(C=C(CC)C(CC)=C4)C3)=CC=C2O)C=C1

5-[(1R)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one

(-20℃)

With Ice Pack

≥ 2 years