α-NETA

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种小分子 CMKLR1 拮抗剂，可抑制凯莫瑞刺激的 β-arrestin2 与 CMKLR1 的关联 (EC50=9.7 nM)。

A small molecule CMKLR1 antagonist that inhibits chemerin-stimulated β-arrestin2 association with CMKLR1 (EC50=9.7 nM); inhibits chemerin-triggered CMKLR1+ cell migration, suppresses CNS autoimmune inflammatory disease in vivo; also inhibits choline acetyltransferase with IC50 of 9 uM.

β-NETA exhibits no effects at muscarinic receptors, ganglionic nicotinic receptors, skeletal muscular nicotinic receptors, cholinesterases or carnitine acetyltransferase at concentrations which inhibits ChA. At concentrations higher than the IC50 value to inhibit ChA, β-NETA antagonizes the effect of acetylcholine (ED50=100 μM), histamine and KCl-induced contractions in the guinea pig longitudinal ileal muscle.

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α-NETA | α NETA | αNETA | alpha NETA

GPCR/G Protein

Chemokine Receptor

Chemokine Receptor

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31059-54-8

369.2

C16H20NO ? I

>98% (HPLC)

In Vitro:?DMSO : 31.25 mg/mL (84.63 mM)

C[N+](C)(CCC(C1=CC=C2C=CC=CC2=C1)=O)C.[I-]

N,N,N-trimethyl-γ-oxo-2-naphthalenepropanaminium, monoiodide

(-20℃)

With Ice Pack

≥ 2 years