KL001

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

KL001 (KL-001) 是一种与隐花色素 (CRY) 和生物钟小分子调节剂特异性相互作用的小分子。

KL001 (KL-001) is a small molecule that specifically interacts with cryptochrome (CRY) and small molecule modulator of the circadian clock; prevents SCFFBXL3-mediated ubiquitination and degradation of CRY, resulting in lengthening of the circadian period, interacts directly with CRY1 and CRY2 and stabilizes CRY proteins; KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes; KL001 is the first-in-class cryptochrome-targeting circadian modulator and substrate-targeting ubiquitination antagonist.

——

——

KL-001 | KL 001

Proteasome/Ubiquitin

DUB

DUB

——

——

309928-48-1

398.477

C21H22N2O4S

>98% (HPLC)

In Vitro:?DMSO : 5 mg/mL (12.55 mM助)

CS(=O)(N(CC(O)CN1C2=C(C3=C1C=CC=C3)C=CC=C2)CC4=CC=CO4)=O

N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)-methanesulfonamide

(-20℃)

With Ice Pack

≥ 2 years