UC-514321

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

UC-514321 是 NSC-370284 的更有效类似物，可直接结合 STAT3/5。

UC-514321 is a more effective analog of NSC-370284 that directly binds to STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo; shows no inhibitory effect on the viability of TET1-low AML (i.e., NB4) cells, function as TET1-transcription inhibitor in TET1-high AMLs and the anti-leukemic effects are TET1-dependent.

Cell Viability Assay Cell Line:MONOMAC-6, THP-1, KOCL-48, KASUMI-1, ML-2, and NB4 cells.Concentration:0-500 nM.Incubation Time:48 hours.Result:Most significantly repressed MONOMAC-6 cell viability. Showed no inhibitory effect on the viability of TET1-low AML.RT-PCR Cell Line:MONOMAC-6 cells.Concentration:0-500 nM.Incubation Time:48 hours.Result:Functioned as TET1-transcription inhibitors in TET1-high AMLs and their anti-leukemic effects are TET1-dependent.

Animal Model:MLL-AF9-AML mice and AE9a-AML model.Dosage:2.5 mg/kg.Administration:IP., once per day, for 10 days. Result:Showed an improved therapeutic effect in AML mouse models in vivo. Prolonged the median survival over three fold.

UC514321

JAK/STAT Signaling

STAT

STAT

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299420-83-0

441.568

C26H35NO5

>98% (HPLC)

In Vitro:?Ethanol : 50 mg/mL (113.23 mM)

——

6-((3,5-di-tert-butyl-4-hydroxyphenyl)(morpholino)methyl)benzo[d][1,3]dioxol-5-ol

(-20℃)

With Ice Pack

≥ 2 years