Bay 41-4109 racemate ( Bay-414109 racemate )

产品货号. M13916 CAS No. 298708-79-9

Bay 41-4109 的外消旋体形式，是 HBV 核衣壳成熟的有效非核苷抑制剂，IC50 为 0.05 uM。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥330	有现货
10MG	￥553	有现货
25MG	￥1014	有现货
50MG	￥1758	有现货
100MG	￥2511	有现货
200MG	￥3573	有现货
500MG	获取报价	有现货
1G	获取报价	有现货
1 mL x 10 mM in DMSO	￥364	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

Bay 41-4109 racemate
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Bay 41-4109 的外消旋体形式，是 HBV 核衣壳成熟的有效非核苷抑制剂，IC50 为 0.05 uM。
产品描述

The racemate form of Bay 41-4109, which is a potent, non-nucleosidic inhibitor of HBV nucleocapsid maturation with IC50 of 0.05 uM.
体外实验

BAY 41-4109 is able to both accelerate and misdirect capsid assembly in vitro. Preformed capsids are stabilized by BAY 41-4109, up to a ratio of one inhibitor molecule per two dimers. BAY 41-4109 is equally effective at inhibiting HBV DNA release and the cytoplasmic HBcAg level, with IC50s of 32.6 and 132 nM in HepG2.2.15 cells, respectively. HBV DNA and HBcAg are inhibited in a dose-dependent manner, indicating that the anti-HBV mechanisms are associated with and dependent on the rate of HBcAg inhibition.
体内实验

BAY 41-4109 reduces viral DNA in the liver and in the plasma dose-dependently with efficacy comparable to 3TC. BAY 41 -4109 reduces hepatitis B virus core antigen (HBcAg) in livers of HBV-transgenic mice. Pharmacokinetic studies in mice have shown rapid absorption, a bioavailability of 30% and dose-proportional plasma concentrations, about 60% in rats and dogs.BAY41-4109 inhibits virus production in vivo by a mechanism that targets the viral capsid.
同义词

Bay-414109 racemate
通路

Microbiology/Virology
靶点

HBV
受体

HBV
研究领域

Infection
适应症

——

化学信息

CAS Number

298708-79-9
分子量

395.7629296
分子式

C18H13ClF3N3O2
纯度

>98% (HPLC)
溶解度

DMSO: ≥ 37 mg/mL
SMILES

CC1=C(C(N=C(N1)C2=C(C=C(C=N2)F)F)C3=C(C=C(C=C3)F)Cl)C(=O)OC
化学全称

5-Pyrimidinecarboxylic acid, 4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoro-2-pyridinyl)-1,4-dihydro-6-methyl-, methyl ester

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Deres K, et al. Science. 2003 Feb 7;299(5608):893-6. 2. Weber O, et al. Antiviral Res. 2002 May;54(2):69-78. 3. Brezillon N, et al. PLoS One. 2011;6(12):e25096.

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