Cinoxacin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

西诺沙星是一种较古老的合成抗菌剂，与喹诺酮类抗生素相关，其活性与奥林酸和萘啶酸类似。

Cinoxacin was an older synthetic antimicrobial related to the quinolone class of antibiotics with activity similar to oxolinic acid and nalidixic acid. (In Vitro):Cinoxacin (0-200μg/mL approximately, 3-24 h) inhibits many gram-negative aerobic bacteria with MIC values ranging from 4 to 64 μg/mL.(In Vivo):Cinoxacin (Oral administration, 1.7 g/kg, treated at 1 and 5 h postinfection) is effective in experimental bacterial infections in mice, with ED50 values ranging from 8.1 to 58.6 mg/kg.

Cinoxacin (0-200μg/mL approximately, 3-24 h) inhibits many gram-negative aerobic bacteria with MIC values ranging from 4 to 64 μg/mL. Cell Proliferation AssayCell Line:Gram-negative aerobic bacteria (Escherichia coli, Proteus sp.etc.)Concentration:0-200μg/mL approximatelyIncubation Time:3-24 hResult:Inhibited basal cell proliferation (40% in FB-2 and 35% in WRO) at 10 μM, inhibited cell number (by 68% to 73%) at 40 and 60 μM).

Cinoxacin (Oral administration, 1.7 g/kg, treated at 1 and 5 h postinfection) is effective in experimental bacterial infections in mice, with ED50 values ranging from 8.1 to 58.6 mg/kg. Animal Model:Indicated bacterial infected mice model Dosage:1.7 g/kg, treated at 1 and 5 h postinfection Administration:Oral administration Result:Displayed antibacterial activity with ED50 values ranging from 8.1 to 58.6 mg/kg.

Cinoxacine | Cinoxacino | Cinoxacinum | Acid, Azolinic | Azolinic Acid

Cell Cycle/DNA Damage

Topoisomerase

Topo II

Infection

——

28657-80-9

262.22

C12H10N2O5

>98% (HPLC)

DMSO: 10 mM

CCN1C2=CC3=C(C=C2C(=O)C(=N1)C(=O)O)OCO3

1-Ethyl-1,4-dihydro-4-oxo[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid

(-20℃)

With Ice Pack

≥ 2 years