Cetilistat

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Cetilistat 是一种胰腺和胃肠道脂肪酶抑制剂。它对糖尿病和非糖尿病患者的肥胖症都有很好的治疗作用。

Cetilistat is an inhibitor of pancreatic and gastrointestinal lipases. It has great treatment of obesity in both diabetic and non-diabetic patients.

Cetilistat inhibits rat pancreatic lipase activity with an IC50 of 54.8 nM. Also, Cetilistat inhibits human pancreatic lipase activity with an IC50 of 5.95 nM, which is 9.2 times more potent than for rat pancreatic lipase.

Cetilistat (3, 10, 30, or 100 mg/kg) reduces intestinal fat absorption by inhibiting pancreatic lipase activity in male SD rats.Cetilistat (4.9, 14.9, or 50.7 mg/kg; mixed into powdered high-fat diet; once a day; for three weeks) shows anti-obesity and antihyperlipidemic effects on DIO F344 rats by reducing intestinal fat absorption. Animal Model:Fifty male SD rats (eight weeks of age)Dosage:3, 10, 30, or 100 mg/kg Administration:Orally administered; prepared in 0.5 % methylcellulose (MC) suspensionResult:Dose-dependently reduced AUC 0-6 h of plasma triglyceride induced by oral loading of Intrafat 20%. The effect was statistically significant at 3 mg/kg, reaching 45% reduction, while an almost 90 % reduction was achieved at 100 mg/kg.Animal Model:Male diet-induced obesity (DIO) F344 rats (five weeks of age)Dosage:4.9, 14.9, or 50.7 mg/kg Administration:Administered as food admixture in a high-fat diet; once a day; for three weeks Result:Significantly and dose-dependently reduced body weight gain compared with control.

ATL-962 | ATL962 | ATL 962 | Cetilistat

Others

Other Targets

Others

Metabolic Disease

——

282526-98-1

401.58

C25H39NO3

>98% (HPLC)

Soluble in DMSO, chloroform

O=C1C2=CC(C)=CC=C2N=C(OCCCCCCCCCCCCCCCC)O1

2-(hexadecyloxy)-6-methyl-4H-benzo[d][1,3]oxazin-4-one

(-20℃)

With Ice Pack

≥ 2 years