MCC950 sodium

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MCC950 (CP-456773) 是一种有效的、选择性的 NLRP3 炎症小体小分子抑制剂，在 BMDM 和 HMDM 中的 IC50 分别为 7.5 和 8.1 nM。

MCC950 (CP-456773) is a potent, selective, small-molecule inhibitor of NLRP3 inflammasome with IC50 of 7.5 and 8.1 nM in BMDM and HMDM, respectively, specifically inhibits activation of NLRP3, does not inhibit NLRC4, AIM2, TLR signalling or priming of NLRP3; blocks NLRP3 induced ASC oligomerization, does not block K+ efflux, Ca2+ flux or NLRP3-ASC interactions; reduces interleukin-1β (IL-1β) production in vivo and attenuates the severity of experimental autoimmune encephalomyelitis (EAE), rescues neonatal lethality in mouse model of CAPS and is active in ex vivo samples from individuals with Muckle-Wells syndrome.

——

——

CP-456773 sodium | CRID3 sodium salt | MCC-950 sodium | CP456773 sodium | CRID-3 sodium salt

NF-κB

NOD

NLRP3

Inflammation/Immunology

——

256373-96-3

426.4618

C20H23N2NaO5S

>98% (HPLC)

H2O: ≥ 30 mg/mL

CC(C)(C1=COC(=C1)S(=O)(=O)[N-]C(=O)NC2=C3CCCC3=CC4=C2CCC4)O.[Na+]

2-Furansulfonamide, N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-, sodium salt (1:1)

(-20℃)

With Ice Pack

≥ 2 years