MPTP-Hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MPTP（盐酸盐）是神经毒素 MPP 的前药，可引起帕金森病的永久性症状。

MPTP (hydrochloride) is a prodrug to the neurotoxin MPP which causes permanent symptoms of Parkinson's disease.(In Vitro):Pretreatment with 50 mM 4-phenylpyridine, reduces IC50 (concentration for 50% inhibition of twitch amplitude) values of MPTP from 53 to 18 mM and d-tubocurarine from 0.7 to 0.3 mM, respectively, in mouse phrenic nerve-diaphragm.(In Vivo):The toxic effect of MPTP can be completely abolished in vivo by treatment with a monoamine oxidase inhibitor and potentiated by an inhibitor of catechol-O-methyltransferase. Gas1 expressions are significantly elevated in the majority of the reactive astrocytes of the brains with LPS or MPTP insults in animal models.

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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | NSC 139654

GPCR/G Protein

Dopamine Receptor

Dopamine

Neurological Disease

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23007-85-4

209.72

C12H16ClN

>98% (HPLC)

DMSO: 12 mg/mL

CN1CCC(=CC1)C2=CC=CC=C2.Cl

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(-20℃)

With Ice Pack

≥ 2 years