BAY-6035 ( BAY6035 )

产品货号. M13611 CAS No. 2247890-13-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

BAY-6035
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

BAY-6035 是一种有效的组蛋白甲基转移酶 SMYD3 肽竞争性抑制剂。
产品描述

BAY-6035 is a potent, peptide-competitive inhibitor of histone methyltransferase SMYD3, inhibits inhibits in vitro methylation of MEKK2 peptide with IC50 of 88 nM, >100-fold selectivity over other HMTases; inhibits the methylation of MEKK2 in cells with IC50 of 70 nM.
体外实验

BAY-6035 inhibits in vitro methylation of MEKK2 peptide with an IC50 of 88 nM and has more than 100-fold selectivity over other histone methyltransferases. BAY-6035 inhibits the methylation of MEKK2 in cells with an IC50 of 70 nM.
体内实验

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同义词

BAY6035
通路

Chromatin/Epigenetic
靶点

HMTase
受体

HMTase
研究领域

——
适应症

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CAS Number

2247890-13-5
分子量

396.491
分子式

C22H28N4O3
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 100 mg/mL (252.22 mM)
SMILES

O=C(C1=CC=C(N(C(N2CC3CC3C2)=O)[C@@H](C)CC(N4)=O)C4=C1)NCCC5CC5
化学全称

(2S)-1-(3-azabicyclo[3.1.0]hexane-3-carbonyl)-N-(2-cyclopropylethyl)-2-methyl-4-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-7-carboxamide