Monensin sodium salt

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Monensin sodium salt 是由肉桂链霉菌 (Streptomyces cinnamonensis) 分泌的抗生素。Monensin sodium salt 是一种介导 Na+/H+ 交换的离子载体。Monensin sodium salt 引起细胞多泡体 (MVBs) 增大并调节外泌体的分泌。

Sodium Monensin, isolated from Streptomyces cinnamonensis, is a well-known representative of naturally polyether ionophore antibiotics.

Cell Viability Assay Cell Line:SCC9, SCC25, and GM-38 cell lines Concentration:1-5 μM Incubation Time:48 h Result:Resulted in a marked decrease in viability in a dose-dependent manner.Apoptosis Analysis Cell Line:SCC25 cells Concentration:1 μM, or 5 μM Incubation Time:24 hours Result:Induced a potent apoptotic response.Western Blot Analysis Cell Line:SCC9 and SCC25 cells Concentration:0.1 μM, or 1 μM Incubation Time:24 hours Result:Induced approximately a 50% inhibition of EGF-treated SCC9 cells with respect to pEGFR and its downstream targets pAKT and pERK.

Animal Model:Multiple intestinal neoplasia (Min) mice (four-week-old) Dosage:10 mg/kg Administration:Orally application; daily; for 6 weeks Result:Suppressed progression of the intestinal tumors without any sign of toxicity on normal mucosa.

Monensin A | NSC 343257 | Rumensin

Others

Other Targets

Others

Other Indications

——

22373-78-0

692.85

C36H61NaO11

>98% (HPLC)

Ethanol: 100 mg/mL (144.33 mM)

CC[C@]1(CC[C@@H](O1)[C@@]2(CC[C@@]3(O2)C[C@@H]([C@H]([C@H](O3)[C@@H](C)[C@H]([C@H](C)C(=O)[O-])OC)C)O)C)[C@H]4[C@H](C[C@@H](O4)[C@@H]5[C@H](C[C@H]([C@@](O5)(CO)O)C)C)C.[Na+]

——

(-20℃)

With Ice Pack

≥ 2 years