AS2541019 ( AS 2541019 )

产品货号. M13323 CAS No. 2098906-98-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

AS2541019
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

AS2541019 是一种新型有效、选择性、口服活性 PI3Kδ 抑制剂，IC50 为 20.1 nM。
产品描述

AS2541019 is a novel potent, selective, orally active PI3Kδ inhibitor with IC50 of 20.1 nM, >100-fold selectivity over other PI3K isoforms; inhibits Akt phosphorylation in human Ramos B cell line with IC50 of 14.3 nM, effectively inhibits anti-IgM stimulated B cell proliferation and human B cell proliferation with IC50 of 4.3 and 3.6 nM, respectively; significantly inhibits both T-dependent and T-independent de novo antibody production in peripheral blood in vivo; significantly prolongs graft survival time by inhibiting xenoreactive antibody production in rat concordant xenotransplant model.
体外实验

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体内实验

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同义词

AS 2541019
通路

PI3K/Akt/mTOR signaling
靶点

PI3K
受体

PI3K
研究领域

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适应症

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CAS Number

2098906-98-8
分子量

529.593
分子式

C26H33F2N7O3
纯度

>98% (HPLC)
溶解度

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SMILES

O=C(N[C@H]1CC[C@H](OC2=NC(N3CCOCC3)=NC(N4C(C(F)F)=NC5=CC=CC=C45)=C2)CC1)CN(C)C
化学全称

N-[trans-4-({6-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-2-(morpholin-4-yl)pyrimidin-4-yl}oxy)cyclohexyl]-2-(dimethylamino)acetamide

1. Marui T, et al. Eur J Pharmacol. 2018 Mar 5. pii: S0014-2999(18)30133-X.

计算器

产品手册

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