Calycosin-7-O-beta-D-glucoside

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Calycosin 7-O-β-D-glucoside 具有抗菌活性。毛蕊异黄酮 7-O-β-D-葡萄糖苷有望成为一种有前景的抗 HIV 药物。

Calycosin 7-O-β-D-glucoside has antimicrobial activity. Calycosin 7-O-β-D-glucoside is anticipated to be a promising anti-HIV agent. It shows scavenging activity to DPPH radicals, and superoxide anion . Calycosin 7-O-β-D-glucopyranoside possesses an alleviating effect on osteoarthritis and can increase the fluidity of brain cell membrane in ischemia-reperfusion rats. Calycosin 7-O-β-D-glucopyranoside possesses a protective effect on rat hepatocytes, an inhibitory effect on COX-2 activity.(In Vitro):Calycosin-7-O-β-D-glucoside (2 μM; 6 hours) remarkably inhibits the expression and activities of MMPs, and secures the expression of cav-1 and tight junction proteins in the microvessels isolated from ischemic rat cortex.(In Vivo):Calycosin-7-O-β-D-glucoside (intraperitoneal injection; 26.8 mg/kg; 14 days) significantly reduces infarct volume, histological damage and BBB permeability in the in vivo MCAO ischemia-reperfusion rat model.

Calycosin-7-O-β-D-glucoside (2 μM; 6 hours) remarkably inhibits the expression and activities of MMPs, and secures the expression of cav-1 and tight junction proteins in the microvessels isolated from ischemic rat cortex.

Calycosin-7-O-β-D-glucoside (intraperitoneal injection; 26.8 mg/kg; 14 days) significantly reduces infarct volume, histological damage and BBB permeability in the in vivo MCAO ischemia-reperfusion rat model. Animal Model:Middle cerebral artery occlusion (MCAO) male adult Sprague-Daweley rats Dosage:26.8 mg/kg Administration:Intraperitoneal injection; 26.8 mg/kg; 14 days Result:Exhibited neuroprotective effects in rats.

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Metabolic Enzyme/Protease

MMP

MMP-2| MMP-9

Other Indications

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20633-67-4

446.4

C22H22O10

>98% (HPLC)

Soluble in Pyridine, Methanol, Ethanol, etc.

COC1=C(C=C(C=C1)C2=COC3=C(C2=O)C=CC(=C3)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O

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(-20℃)

With Ice Pack

≥ 2 years