HBV Capsid inhibitor 3711 ( Compound 3711 )

产品货号. M13173 CAS No. 2041072-40-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

HBV Capsid inhibitor 3711
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

HBV 衣壳抑制剂 3711（化合物 3711）是一种非核苷 HBV 抑制剂。
产品描述

HBV Capsid inhibitor 3711 (Compound 3711) is a nonnucleosidic HBV inhibitor, inhibits hepatitis B virus replication by inducing genome-free capsid formation; decreases extracellular HBV DNA levels and intracellular DNA levels with EC50 of 1.5 and 1.9 uM in a cell model system; shows sensitivity against both the 3TC/ETV dually resistant L180M/M204I mutant and the adefovir (ADV)-resistant A181T/N236T mutant; decreases levels of HBV DNA contained in both secreted enveloped virion and naked virus particles in supernatant, interferes with capsid formation of the core protein (Cp) assembly domain.
体外实验

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体内实验

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同义词

Compound 3711
通路

Microbiology/Virology
靶点

HBV
受体

HBV
研究领域

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适应症

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CAS Number

2041072-40-4
分子量

367.833
分子式

C20H18ClN3O2
纯度

>98% (HPLC)
溶解度

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SMILES

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化学全称

N-(4-(1-(4-chlorobenzyl)-5-methyl-6-oxo-1,6-dihydropyridazin-3-yl)phenyl)acetamide

1. Feng S, et al. ACS Infect Dis. 2018 Mar 9;4(3):257-277. 2. Wang YJ, et al. Antimicrob Agents Chemother. 2015 Nov;59(11):7061-72.

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