BI 6901 ( BI6901 )

产品货号. M13172 CAS No. 2040401-92-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

BI 6901
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

BI 6901 是一种有效的选择性 CCR10 拮抗剂，水母蛋白 Ca2+ 通量 pIC50 为 9.0。
产品描述

BI 6901 is a potent, selective CCR10 antagonist with Aequorin Ca2+ flux pIC50 of 9.0, shows high selectivity over other GPCRs; inhibits the CCL27 dependent chemotaxis of Ba/F3 cells stably transfected with human CCR10 with pIC50 of 9.0, BI 6901 is efficacious in a murine model of DNFB contact hypersensitivity, inhibits DNFB stimulated inflammatory response in sensitized Balb-C mice.
体外实验

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体内实验

Animal Model:Balb-C mice with a DNFB model of contact hypersensitivity.Dosage:100 mg/kg Administration:Intraperitoneal?injection Result:Had a inhibitory effect on the DNFB stimulated inflammatory response in sensitized Balb-c mice.
同义词

BI6901
通路

GPCR/G Protein
靶点

Chemokine Receptor
受体

Chemokine Receptor
研究领域

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适应症

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CAS Number

2040401-92-9
分子量

453.561
分子式

C23H27N5O3S
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 160 mg/mL (352.76 mM)
SMILES

O=S(C1=CC=CC2=C1C=CN2)(N[C@H](CCN3C(C#N)=CC=C3)C(N4CCC(C)CC4)=O)=O
化学全称

N-[(2R)-4-(2-cyanopyrrol-1-yl)-1-(4-methylpiperidin-1-yl)-1-oxobutan-2-yl]-1H-indole-4-sulfonamide