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BIBO 3304
CAS No. 191868-14-1
BIBO 3304 ( BIBO3304 )
产品货号. M13008 CAS No. 191868-14-1
BIBO 3304 是一种有效的、选择性的非肽神经肽 Y Y1 受体拮抗剂，对人和大鼠 Y1 受体的 IC50 分别为 0.38 和 0.72 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥1197 | 有现货 |
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| 5MG | ￥1891 | 有现货 |
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| 10MG | ￥3354 | 有现货 |
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| 25MG | ￥5348 | 有现货 |
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| 50MG | ￥7282 | 有现货 |
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| 100MG | ￥9630 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥2309 | 有现货 |
|
生物学信息
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产品名称BIBO 3304
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述BIBO 3304 是一种有效的、选择性的非肽神经肽 Y Y1 受体拮抗剂，对人和大鼠 Y1 受体的 IC50 分别为 0.38 和 0.72 nM。
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产品描述BIBO 3304 is a potent, selective, nonpeptide neuropeptide Y Y1 receptor antagonist with IC50 of 0.38 and 0.72 nM for human and the rat Y1 receptor, respectively; shows low affinity for the human Y2 receptor, human and rat Y4 receptor, human and rat Y5 receptor (IC50>1,000 nM); inhibits the feeding response induced by 1 mg NPY in mice, also completely abolishes PYY-induced inhibition of insulin release in vivo.Obesity Discontinued(In Vivo):BIBO3304 TFA (30 μg; bilateral paraventricular nucleus injection) attenuates the hyperphagia following fasting.BIBO3304 TFA (15-60 μg) dose-dependently inhibits the feeding reponse mediated by 1 μg NPY.BIBO3304 TFA (0.5?μM; p.o.) significantly increases serum insulin levels.
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体外实验——
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体内实验BIBO3304 TFA (30 μg; bilateral paraventricular nucleus injection) attenuates the hyperphagia following fasting.BIBO3304 TFA (15-60 μg) dose-dependently inhibits the feeding reponse mediated by 1 μg NPY.BIBO3304 TFA (0.5?μM; p.o.) significantly increases serum insulin levels. Animal Model:Adult male Chbb:Thom rats weighing between 300 and 340 g Dosage:30 μg Administration:bilateral paraventricular nucleus injection Result:Attenuated the hyperphagia following fasting, especially during the first 2 h of refeeding.Animal Model:7-week-old C57BL/6JAusb mice Dosage:0.5?μM Administration:p.o.Result:Significantly increased serum insulin levels.
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同义词BIBO3304
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通路GPCR/G Protein
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靶点Neuropeptide Y Receptor
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受体Neuropeptide Y Receptor
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研究领域Metabolic Disease
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适应症Obesity
化学信息
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CAS Number191868-14-1
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分子量643.668
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分子式C31H36F3N7O5
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 100 mg/mL (155.36 mM)
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SMILESC1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NCC3=CC=C(C=C3)CNC(=O)N
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化学全称(R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-(ureidomethyl)benzyl)pentanamide 2,2,2-trifluoroacetate
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
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MK-0557
MK-0557 是一种选择性口服神经肽 Y5 受体拮抗剂 (Ki: 1.6 nM)。
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CART (55-102) (rat)
Cocaine- and amphetamine-regulated transcript (CART) with potent appetite-suppressing activity. Satiety factor; inhibits normal and starvation-induced feeding. Closely related to the actions of leptin and neuropeptide Y; blocks the neuropeptide Y-induced feeding response. Induces anxiety and stress behavior in rodents.
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[D-Trp34]-Neuropepti...
Potent neuropeptide Y (NPY) Y5 receptor agonist (pEC50 values are 7.82, 6.28, 6.44 and > 6 at rat Y5, Y4, Y1 and Y2 receptors respectively) that displays > 26-fold, > 1000-fold and > 1000-fold selectivity over Y1, Y2 and Y4 receptors respectively. Induces hyperphagia, body weight gain, adiposity, hypercholesterolemia, hyperinsulinemia and hyperleptinemia in vivo. Orally active.
