BAY-1816032

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BAY-1816032 (BAY1816032) 是一种高效、选择性、口服活性的 BUB1 有丝分裂检查点丝氨酸/苏氨酸激酶，IC50 为 7 nM。

BAY-1816032 (BAY1816032) is a highly potent, selective, orally active BUB1 mitotic checkpoint serine/threonine kinase with IC50 of 7 nM, displays excellent selectivity on a panel of 395 kinases; abrogates nocodazole-induced Thr-120 phosphorylation of the major BUB1 target protein histone H2A in HeLa cells with IC50 of 29 nM, induces lagging chromosomes and mitotic delay, inhibits proliferation of various tumor cell lines with mean IC50 of 1.4 uM; demonstrates synergy or additivity with paclitaxel or docetaxel both in vitro and in vivo.

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BAY1816032

Angiogenesis

Chk

Chk

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1891087-61-8

534.524

C27H24F2N6O4

>98% (HPLC)

DMSO : 25 mg/mL 46.77 mM; H2O : < 0.1 mg/mL

COC1=CN=C(N=C1NC2=C(C=NC=C2)OC)C3=NN(C4=CC=CC=C43)CC5=C(C=C(C=C5F)OCCO)F

2-[3,5-Difluoro-4-[[3-[5-methoxy-4-[(3-methoxy-4-pyridinyl)amino]-2-pyrimidinyl]-1H-indazol-1-yl]methyl]phenoxy]ethanol

(-20℃)

With Ice Pack

≥ 2 years