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BAY-1816032
CAS No. 1891087-61-8
BAY-1816032 ( BAY1816032 )
产品货号. M12963 CAS No. 1891087-61-8
BAY-1816032 (BAY1816032) 是一种高效、选择性、口服活性的 BUB1 有丝分裂检查点丝氨酸/苏氨酸激酶，IC50 为 7 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥701 | 有现货 |
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| 10MG | ￥1131 | 有现货 |
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| 25MG | ￥2213 | 有现货 |
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| 50MG | ￥3302 | 有现货 |
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| 100MG | ￥4419 | 有现货 |
|
| 200MG | ￥5922 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥758 | 有现货 |
|
生物学信息
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产品名称BAY-1816032
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述BAY-1816032 (BAY1816032) 是一种高效、选择性、口服活性的 BUB1 有丝分裂检查点丝氨酸/苏氨酸激酶，IC50 为 7 nM。
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产品描述BAY-1816032 (BAY1816032) is a highly potent, selective, orally active BUB1 mitotic checkpoint serine/threonine kinase with IC50 of 7 nM, displays excellent selectivity on a panel of 395 kinases; abrogates nocodazole-induced Thr-120 phosphorylation of the major BUB1 target protein histone H2A in HeLa cells with IC50 of 29 nM, induces lagging chromosomes and mitotic delay, inhibits proliferation of various tumor cell lines with mean IC50 of 1.4 uM; demonstrates synergy or additivity with paclitaxel or docetaxel both in vitro and in vivo.
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体外实验——
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体内实验——
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同义词BAY1816032
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通路Angiogenesis
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靶点Chk
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受体Chk
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研究领域——
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适应症——
化学信息
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CAS Number1891087-61-8
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分子量534.524
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分子式C27H24F2N6O4
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纯度>98% (HPLC)
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溶解度DMSO : 25 mg/mL 46.77 mM; H2O : < 0.1 mg/mL
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SMILESCOC1=CN=C(N=C1NC2=C(C=NC=C2)OC)C3=NN(C4=CC=CC=C43)CC5=C(C=C(C=C5F)OCCO)F
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化学全称2-[3,5-Difluoro-4-[[3-[5-methoxy-4-[(3-methoxy-4-pyridinyl)amino]-2-pyrimidinyl]-1H-indazol-1-yl]methyl]phenoxy]ethanol
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Gerhard Siemeister, et al. Abstract 287: BAY 1816032, a novel BUB1 kinase inhibitor with potent antitumor activity. AACR. DOI: 10.1158/1538-7445.
2.?Siemeister G, et al. Clin Cancer Res. 2018 Nov 14. pii: clincanres.0628.2018.
