BI8626 ( BI-8626 | BI 8626 )

产品货号. M12906 CAS No. 1875036-75-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

BI8626
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

BI8626 (BI-8626) 是 HUWE1 泛素连接酶的特异性小分子抑制剂，IC50 为 0.9 uM。
产品描述

BI8626 (BI-8626) is a specific, small molecule inhibitor of the HUWE1 ubiquitin ligase with IC50 of 0.9 uM, does not inhibit the activity of other HECT-domain ubiquitin ligases (HECW2, NEDD4,UBA1 and UbcH5b, IC50>50 uM); suppresses colony formation of Ls174T cells with IC50 of 0.7 uM; inhibits MYC-dependent transactivation in colorectal cancer cells, but not in stem and normal colon epithelial cells; stabilizes MYC-associated protein MIZ1.
体外实验

Cell Cycle Analysis Cell Line:Ls174T cells Concentration:0 μM, 5 μM,10 μM, 15 μM, 20 μM Incubation Time:0-4 days Result:Retarded passage of Ls174T cells through all phases of the cell cycle, with the effect being strongest for G1.Western Blot Analysis Cell Line:U2OS cells Concentration:0 μM, 20 μM, 50 μM Incubation Time:0 hour,1 hour,2 hours,4 hours,6 hours Result:Retarded the degradation of MCL1 in response to UV irradiation in HeLa cells by inhibiting HUWE1 in U2OS cells.
体内实验

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同义词

BI-8626 | BI 8626
通路

Proteasome/Ubiquitin
靶点

E3 Ubiquitin Ligase
受体

E3 Ubiquitin Ligase
研究领域

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适应症

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CAS Number

1875036-75-1
分子量

440.555
分子式

C25H28N8
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 83.33 mg/mL (189.15 mM)
SMILES

NCC1=CC(CNC2=C(N=CN=C3N4CCN(CC5=CC=CC=C5)CC4)C3=NC=N2)=CC=C1
化学全称

N-(3-(aminomethyl)benzyl)-8-(4-benzylpiperazin-1-yl)pyrimido[5,4-d]pyrimidin-4-amine

1. Peter S, et al. EMBO Mol Med. 2014 Dec;6(12):1525-41.

计算器

产品手册

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