HEC72702

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

HEC72702 是一种新型有效、口服活性的 HBV 衣壳组装抑制剂，可抑制 HepG.2.2.15 细胞中的 HBV-DNA 水平，IC50 为 39 nM。

HEC72702 is a novel potent, orally active inhibitor of HBV capsid assembly, inhibits HBV-DNA levels in HepG.2.2.15 cells with IC50 of 39 nM; displays no induction of the CYP1A2, CYP3A4, or CYP2B6 enzyme at 10 uM, demonstrates a good systemic exposure and high oral bioavailability and achieves a viral-load reduction greater than 2 log in a hydrodynamic-injected (HDI) HBV mouse model.

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Animal Model:6-7 weeks, 16-18 g, Female BALB/c mice(HDI mouse model)Dosage:50, 100 mg/kg Administration:P.o.; daily for 7 days Result:Demonstrated a dose-dependent reduction of HBV DNA in the plasma of infected mice.

HEC-72702 | HEC 72702

Microbiology/Virology

HBV

HBV

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1793063-59-8

581.457

C24H26BrFN4O5S

>98% (HPLC)

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O=C(OCC)C1=C(NC(C2=NC=CS2)=N[C@H]1C3=C(Br)C=C(F)C=C3)CN4CCO[C@H](CCC(O)=O)C4

3-((R)-4-(((R)-6-(2-Bromo-4- fluorophenyl)-5-(ethoxycarbonyl)-2-(thiazol-2-yl)- 3,6-dihydropyrimidin-4-yl)methyl)morpholin-2-yl)propanoic acid

(-20℃)

With Ice Pack

≥ 2 years