GZ389988 ( GZ-389988 | GZ 389988 )

产品货号. M12693 CAS No. 1788906-96-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

GZ389988
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

GZ389988 (GZ-389988) 是一种新型强效、选择性、局部递送的 TrkA 抑制剂，用于治疗骨关节炎；显示 TrkA、TrkB 和 TrkC 以及生长因子受体 cFMS (CSF1R) 的相似 IC50 值。
产品描述

GZ389988 (GZ-389988) is a novel potent, selective, locally delivered TrkA inhibitor for the treatment osteoarthritis; shows similar IC50 values for TrkA, TrkB and TrkC, and the growth factor receptor cFMS (CSF1R), GZ389988 is highly selective against a wide panel of other kinases; GZ389988 can significantly reduces local joint pain, without effect on ipsilateral joint pain; GZ389988 also is efficacious in the PGPS arthritis model, demonstrating a significant improvement of gait analysis scores following painful disease reactivation flares.Other Indication Phase 2 Clinical.
体外实验

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体内实验

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同义词

GZ-389988 | GZ 389988
通路

Tyrosine Kinase
靶点

Trk Receptor
受体

Trk Receptor
研究领域

Other Indications
适应症

Other Disease

CAS Number

1788906-96-6
分子量

470.533
分子式

C26H26N6O3
纯度

>98% (HPLC)
溶解度

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SMILES

NC1=NC2=CC(C3=CN(C)N=C3)=CN=C2N1CC4=CC=C(OCC5=CC=C(OC)C=C5)C(OC)=C4
化学全称

3-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)-6-(1-methyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-2-amine

计算器

产品手册

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