CCT007093

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CCT007093 是一种有效的 PPM1D (WIP1) 抑制剂，IC50 为 8.4 μM。

CCT007093 is a potent PPM1D (WIP1) inhibitor with IC50 of 8.4 μM.

CCT007093 (25 or 50 μM, 8 h) significantly increases the phosphorylation levels of mTOR at Ser2448, Ser2481 and Ser2159, and the phosphorylation levels of p70S6K (Thr389) and S6 (Ser235/236) are also up-regulated in transfected HEK293T cell line.CCT007093 shows specificity for MCF-7 cells, reducing viability by 40% after 2 days with no observable effect on the growth of HeLa cells.CCT007093 induces P38 phosphorylation at 4 h post exposure in MCF-7 cells (sensitive to PPM1D inhibition), and does not induce P38 phosphorylation in HeLa cells (relatively resistant to PPM1D inhibition). Western Blot AnalysisCell Line:HEK293T cell line.Concentration:25 or 50 μM.Incubation Time:8 h.Result:The phosphorylation levels of mTOR at Ser2448, Ser2481 and Ser2159 were all significantly increased.

CCT007093 (6.4 mg/kg) enhances liver regeneration and increases the survival rate of mice following major hepatectomy. Animal Model:Wild-type mice.Dosage:3.2 and 6.4 mg/kg. Administration:Injected intraperitoneally 4 times (mice were sacrificed at 36 h post-PH).Result:Significantly improved survival in mice following major hepatectomy (80% hepatectomy).The level of PCNA was also significantly increased in the liver of CCT007093-treated mice at 36h, 48h and 72h post-PH.

CCT007093 | CCT-007093 | CCT 007093.

Metabolic Enzyme/Protease

Phosphatase

PPM1D

Cancer

——

176957-55-4

272.39

C15H12OS2

>98% (HPLC)

DMSO: 1 mg/mL warmed (3.67 mM)

O=C1/C(CC/C1=C\C2=CC=CS2)=C/C3=CC=CS3

(2E,5E)-2,5-Bis(2-thienylmethylene)-cyclopentanone.

(-20℃)

With Ice Pack

≥ 2 years