BI 894999 ( BI894999 )

产品货号. M12534 CAS No. 1660117-38-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

BI 894999
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

BI 894999 是一种新型有效的选择性 BET 抑制剂，对 BRD4-BD1 和 BRD4-BD2 溴结构域的 IC50 分别为 5 和 41 nM。
产品描述

BI 894999 is a novel potent, selective BET inhibitor with IC50 of 5 and 41 nM for BRD4-BD1 and BRD4-BD2 bromodomains, respectively; displays excellent selectivity over other bromodomains; decreases S-Phase and increases apoptosis, Volasertib augments and prolongs the decrease of MYC expression caused by BI 894999 treatment in AML cell lines; dramatically reduces tumor burden accompanied by eradication of AML cells in mouse bone marrow combined with Volasertib; also represses super-enhancer-associated transcription and synergizes with CDK9 inhibition in AML.Solid Tumors Phase 1 Clinical
体外实验

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体内实验

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同义词

BI894999
通路

Chromatin/Epigenetic
靶点

Bromodomain
受体

Bromodomain
研究领域

Cancer
适应症

Solid Tumors

CAS Number

1660117-38-3
分子量

429.524
分子式

C25H27N5O2
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 125 mg/mL (291.03 mM)
SMILES

CN1C(C(C)=CC(C2=NC3=CN=C(C4CCOCC4)C=C3N2[C@@H](C)C5=CC=CC=C5)=N1)=O
化学全称

(S)-2,4-dimethyl-6-(1-(1-phenylethyl)-6-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]pyridin-2-yl)pyridazin-3(2H)-one