DprE1-IN-25 ( MDK3875 | MDK-3875 | MDK 3875 | DprE1-IN-2 | DprE1IN2 )

产品货号. M12351 CAS No. 1615713-87-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

DprE1-IN-25
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

一种有效的非共价 DprE1 抑制剂，IC50 为 43 nM，在体外显示出抗结核分枝杆菌 (Mtb) 的活性，MIC 为 0.39 uM。
产品描述

A potent, noncovalent DprE1 inhibitor with IC50 of 43 nM, shows activity against Mycobacterium tuberculosis (Mtb) in vitro with MIC of 0.39 uM.
体外实验

——
体内实验

DprE1-IN-2 (compound 18; oral; 100 mg/kg) has t1/2 of 0.9 hours and Cmax of 70 μM in BALB/c Mice. Animal Model:BALB/c Mice Dosage:100 mg/kg Administration:Oral Result:Had t1/2 of 0.9 hours and Cmax of 70 μM.
同义词

MDK3875 | MDK-3875 | MDK 3875 | DprE1-IN-2 | DprE1IN2
通路

GPCR/G Protein
靶点

Antibacterial
受体

DprE
研究领域

Cancer
适应症

——

CAS Number

1615713-87-5
分子量

368.4329
分子式

C19H24N6O2
纯度

>98% (HPLC)
溶解度

DMSO: ≥ 33 mg/mL
SMILES

O=C(C1=CN(CC2=NC=NC(N(C)C)=C2C)C3=CC(C)=CN=C31)NCCO
化学全称

1H-Pyrrolo[3,2-b]pyridine-3-carboxamide, 1-[[6-(dimethylamino)-5-methyl-4-pyrimidinyl]methyl]-N-(2-hydroxyethyl)-6-methyl-

1. Shirude PS, et al. J Med Chem. 2014 Jul 10;57(13):5728-37.

计算器

产品手册

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