HTH-01-015 ( HTH 01 015 )

产品货号. M12346 CAS No. 1613724-42-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

HTH-01-015
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

HTH-01-015 是一种有效的、特异性的 NUAK1（AMPK 相关激酶 5，ARK5）抑制剂，IC50 为 100 nM。
产品描述

HTH-01-015 is a potent, specific NUAK1 (AMPK-related kinase 5, ARK5) inhibitor with IC50 of 100 nM, displays >100-fold higher potency than NUAK2; also does not markedly suppress the activity of any of the other 139 protein kinases, including AMPK; suppresses NUAK1-mediated MYPT1 phosphorylation in vivo, the NUAK1 mutation (A195T) renders resistant to HTH-01-015; significantly inhibits migration the proliferation of MEFs (mouse embryonic fibroblasts).
体外实验

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体内实验

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同义词

HTH 01 015
通路

Membrane Transporter/Ion Channel
靶点

AMPK
受体

NUAK1|NUAK2
研究领域

Cancer
适应症

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CAS Number

1613724-42-7
分子量

468.5535
分子式

C26H28N8O
纯度

>98% (HPLC)
溶解度

10 mM in DMSO
SMILES

CC1=C(N(C)C(C2=CC(C=CC=C3)=C3C=C2N4C)=O)C4=NC(NC5=CN(N=C5)C6CCNCC6)=N1
化学全称

6H-Naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one, 5,13-dihydro-4,5,13-trimethyl-2-[[1-(4-piperidinyl)-1H-pyrazol-4-yl]amino]-