021-51111890
购物车（）
sales@molnova.cn
Frovatriptan
CAS No. 158930-17-7
Frovatriptan ( —— )
产品货号. M12269 CAS No. 158930-17-7
一种有效、长效的 5-HT(1B/1D) 受体激动剂，可作为抗偏头痛化合物。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥487 | 有现货 |
|
| 10MG | ￥787 | 有现货 |
|
| 25MG | ￥1386 | 有现货 |
|
| 50MG | ￥2065 | 有现货 |
|
| 100MG | ￥2961 | 有现货 |
|
| 200MG | ￥4302 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥407 | 有现货 |
|
生物学信息
-
产品名称Frovatriptan
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述一种有效、长效的 5-HT(1B/1D) 受体激动剂，可作为抗偏头痛化合物。
-
产品描述A potent, long lasting 5-HT(1B/1D) receptor agonist as a antimigraine agent.Migraine Appoved.
-
体外实验Cerebral vasodilatation and neurogenic inflammation are considered to be prime movers in the pathogenesis of migraine. Activation of 5-HT1B reverses cerebral vasodilatation and activation of 5-HT1D prevents neurogenic inflammation. Frovatriptan has a high affinity for 5-HT1B and 5-HT1D receptors and a moderate affinity for the 5-HT1A and 5-HT1F receptors subtypes. Frovatriptan has a moderate affinity for the 5-HT7 receptors, an action associated with coronary artery relaxation in the dog.
-
体内实验Oral bioavailability of Frovatriptan is 22%-30% and is not affected by food. Although the maximum concentration in the plasma is achieved in 2-3 hours, 60%-70% of this is achieved in 1 hour. A steady state is achieved in 4-5 days. Plasma protein binding is low at 15%. The most unique feature is the relative terminal long half-life of about 26 hours. Frovatriptan is chiefly metabolized by CYP1A2 and is cleared by the kidney and liver making moderate failure of either organ not a limiting factor in treatment.Frovatriptan (0.1, 0.2, and 0.3 mg/kg; a single bolus intraduodenal administration) treatment produces an increase in carotid vascular resistance, which is sustained for at least 5 hours in dogs.
-
同义词——
-
通路GPCR/G Protein
-
靶点5-HT Receptor
-
受体5-HT Receptor
-
研究领域Neurological Disease
-
适应症Migraine
化学信息
-
CAS Number158930-17-7
-
分子量361.398
-
分子式C18H23N3O5
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO : 100 mg/mL (263.57 mM)
-
SMILESCNC1CCC2=C(C1)C3=C(N2)C=CC(=C3)C(=O)N.C(CC(=O)O)C(=O)O.O
-
化学全称(R)-3-(methylamino)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamide succinate
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
-
DA-6886
DA-6886 is an agonist 5-Hydroxytryptamine receptor 4 (5-HT4). DA-6886 induced relaxation of the rat oesophagus preparation in a 5-HT4 receptor antagonist-sensitive manner. The evaluation of DA-6886 in CHO cells expressing hERG channels revealed that it inhibited hERG channel current with an pIC50 value of 4.3, indicating that the compound was 1000-fold more selective for the 5-HT4 receptor over hERG channels.
-
Citalopram
Citalopram 是一种包含活性 S(+)-对映体 (Escitalopram；HY-14258) 和 R(-)-对映体的外消旋混合物。Citalopram 是一种具有口服活性的、选择性血清素再摄取抑制剂 (SSRI)。Citalopram是一种抗抑郁药，可增强血清素能神经传递。
-
LY 272015 hydrochlor...
LY-272015 hydrochloride 是一种具有口服活性的，特异性 5-HT2B 受体拮抗剂。LY-272015 hydrochloride 完全抑制 5-HT 或 BW723C86 诱导的 ERK2 磷酸化。LY-272015 hydrochloride 在醋酸去氧皮质酮 (DOCA)-盐高血压大鼠中具有抗高血压作用。
