PF-06648671 ( PF6648671 )

产品货号. M12266 CAS No. 1587727-31-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

PF-06648671
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

PF-06648671 (PF6648671) 是一种新型口服γ-分泌酶调节剂，正在开发用于治疗阿尔茨海默病。
产品描述

PF-06648671 (PF6648671) is a novel oral γ-secretase modulator being developed for the treatment of Alzheimer's disease.Alzheimer Disease Phase 1 Discontinued.
体外实验

In a cell-based assay, PF-06648671 reduces Aβ42 and Aβ40 , with concomitant increases in Aβ37 and Aβ38, without inhibiting the cleavage of Notch or other substrates.
体内实验

PF-06648671 demonstrates reduces Aβ42 within the brain and CSF following acute oral administration in animals.
同义词

PF6648671
通路

Wnt/Notch/Hedgehog
靶点

γ-secretase
受体

γ-secretase
研究领域

——
适应症

——

CAS Number

1587727-31-8
分子量

538.928
分子式

C25H23ClF4N4O3
纯度

>98% (HPLC)
溶解度

——
SMILES

O=C1C(N2CCN1[C@H]([C@H]3O[C@@H](C4=CC(F)=C(Cl)C=C4C(F)(F)F)CC3)C)=CC=C(N5C=C(C)N=C5)C2=O
化学全称

2H-Pyrido[1,2-a]pyrazine-1,6-dione, 2-[(1S)-1-[(2S,5R)-5-[4-chloro-5-fluoro-2-(trifluoromethyl)phenyl]tetrahydro-2-furanyl]ethyl]-3,4-dihydro-7-(4-methyl-1H-imidazol-1-yl)-