Marimastat

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种针对 MMP9/1/2/14/7 的广谱 MMP 抑制剂，IC50 分别为 3/5/6/9/13 nM。

A broad spectrum MMP inhibitor for MMP9/1/2/14/7 with IC50 of 3/5/6/9/13 nM, respectively.Lung Cancer Phase 3 Clinical(In Vitro):Marimastat (BB2516) (1 μM) shows inhibition of vascular outgrowth, and selectively affects angiogenesis.(In Vivo):Animals receiving chemoradiation + Marimastat (BB2516) (8.7 mg/kg) have statistically significant delayed growth, compared to animals receiving chemoradiation alone. Marimastat (BB2516) may work in combination with chemotherapy and radiation to inhibit tumor growth.

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BB-2516 | TA-2516

Metabolic Enzyme/Protease

MMP

MMP-1| MMP-14| MMP-2| MMP-7| MMP-9

Cancer

Lung Cancer

154039-60-8

331.4079

C15H29N3O5

>98% (HPLC)

DMSO: ≥ 140 mg/mL

O=C(N[C@@H](C(C)(C)C)C(NC)=O)[C@H](CC(C)C)[C@H](O)C(NO)=O

Butanediamide, N4-[(1S)-2,2-dimethyl-1-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)-, (2S,3R)-

(-20℃)

With Ice Pack

≥ 2 years