Sevelamer HCl

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Sevelamer HCl 是一种磷酸盐结合化合物，用于通过与膳食磷酸盐结合并阻止其吸收来治疗高磷血症。

Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption.

Sevelamer hydrochloride (15 mg/mL; pH=6 or 8) decreases serum levels of gut-derived uremic toxins (such as IAA) or limits the elevation of gut-derived uremic toxins (initial concentration=1 μg/mL or 10 μg/mL).

Sevelamer hydrochloride (1% mixed in diet; p.o.; once daily for 5 weeks) reduces Npt2b-deficient mice serum phosphate levels, but fails to reduce the level in uremic WT mice.Sevelamer hydrochloride leads to a significant decrease in osteoclast number in uremic WT mice with a trend toward further decrease in Npt2b-/- mice.Sevelamer hydrochloride leads to a significant increase in Npt2b protein expression.

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Others

Other Targets

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Other Indications

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152751-57-0

186.08

(C?H?N . C?H?ClO)x . x HCl

>98% (HPLC)

DMSO:<1 mg/mL; Ethanol:<1 mg/mL; Water:<1 mg/mL

C=CCN.C1C(O1)CCl.Cl

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(-20℃)

With Ice Pack

≥ 2 years