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Nalfurafine hydrochloride
CAS No. 152658-17-8
Nalfurafine hydrochloride ( TRK-820 hydrochloride )
产品货号. M12135 CAS No. 152658-17-8
Nalfurafine (TRK-820、TRK820) 是一种有效的选择性 κ 阿片受体激动剂，Ki 为 3.5 nM，对 μOR 的效力低 15 倍，对 δOR 的亲和力很小（Ki 分别为 53 和 1,200 nM）。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥1717 | 有现货 |
|
| 5MG | ￥2908 | 有现货 |
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| 10MG | ￥4317 | 有现货 |
|
| 25MG | ￥6990 | 有现货 |
|
| 50MG | ￥9639 | 有现货 |
|
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Nalfurafine hydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Nalfurafine (TRK-820、TRK820) 是一种有效的选择性 κ 阿片受体激动剂，Ki 为 3.5 nM，对 μOR 的效力低 15 倍，对 δOR 的亲和力很小（Ki 分别为 53 和 1,200 nM）。
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产品描述Nalfurafine (TRK-820, TRK820) is potent, selective agonist of kappa-opioid receptor with Ki of 3.5 nM, 15-fold less potent for μOR and little affinity for δOR (Ki=53 and 1,200 nM, respectively); also potently binds to mutant κ(E297K), μ(K303E), κ(E297W) and κ(E297A) with Ki of 10-50 nM; inhibits forskolin-stimulated intracellular cAMP accumulation with IC50 of 0.15 nM, which is 100 fold smaller than that of U69593; produces potent antinociceptive effects in vivo.Other Indication Approved.
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体外实验——
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体内实验——
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同义词TRK-820 hydrochloride
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通路Endocrinology/Hormones
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靶点Opioid Receptor
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受体κ-opioidreceptor
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研究领域Other Indications
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适应症Other Disease
化学信息
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CAS Number152658-17-8
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分子量513.025
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分子式C28H33ClN2O5
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纯度>98% (HPLC)
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溶解度DMSO: 21 mg/mL
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SMILESCN(C1CCC2(C3CC4=C5C2(C1OC5=C(C=C4)O)CCN3CC6CC6)O)C(=O)C=CC7=COC=C7.Cl
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化学全称2-Propenamide, N-[(5α,6β)-17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]-3-(3-furanyl)-N-methyl-, hydrochloride (1:1), (2E)-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Nagase H, et al. Chem Pharm Bull (Tokyo). 1998 Feb;46(2):366-9.
2. Seki T, et al. Eur J Pharmacol. 1999 Jul 2;376(1-2):159-67.
3. Endoh T, et al. Life Sci. 1999;65(16):1685-94.
4. Endoh T, et al. Eur J Pharmacol. 2000 Jan 10;387(2):133-40.
产品手册
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