Vorinostat

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种有效的 HDAC 抑制剂，抑制 HDAC1 和 HDAC3 的活性，IC50 分别为 10 nM 和 20 nM。

A potent HDAC inhibitor, inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively; inhibits cell growth, induce terminal differentiation and prevent the formation of tumours in mice models.Blood Cancer Approved(In Vitro):Vorinostat efficiently suppresses MES-SA cell growth at a low dosage (3 μM) already after 24 hours treatment. HDACs class I (HDAC2 and 3) as well as class II (HDAC7) are preferentially affected by this treatment. Vorinostat significantly increases p21WAF1 expression and apoptosis in MES-SA cells.Vorinostat inhibits SK-N-SH and SK-N-Be(2)C with the IC25 values of 1 μM and 0.5 μM, respectively.Vorinostat is an effective inhibitor of HPV-18 DNA amplification, reduces oncoproteins E6 and E7 activities and triggers apoptosis in HPV-infected, differentiated cells.(In Vivo):Vorinostat (50 mg/kg/day) reduces tumor growth by more than 50% in nude mice injected with 5×106 MES-SA cells.

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Vorinostat (50 mg/kg/day) reduces tumor growth by more than 50% in nude mice injected with 5×106 MES-SA cells.

SAHA | Suberoylanilide hydroxamic acid | MK-0683

Cell Cycle/DNA Damage

HDAC

HDAC|HDAC1|HDAC2|HDAC3|HDAC6|HDAC8

Cancer

Blood cancer

149647-78-9

264.3202

C14H20N2O3

>98% (HPLC)

DMSO: ≥ 100 mg/mL

O=C(NO)CCCCCCC(NC1=CC=CC=C1)=O

Octanediamide, N1-hydroxy-N8-phenyl-

(-20℃)

With Ice Pack

≥ 2 years