Hydroxyquinoline

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

8-Hydroxyquinoline 是一种单质子二齿螯合剂，具有防腐、消毒和杀虫剂特性。

8-Hydroxyquinoline is a monoprotic bidentate chelating agent, exhibits antiseptic, disinfectant, and pesticide properties, functioning as a transcription inhibitor.

Cell Viability Assay Cell Line:DCIS cells Concentration:1,2.5,5,10,20 μM Incubation Time:1 or 8 hour Result:Binding to copper and form complexes make the cells rounded up and detached, induces cell death with in a concentration- and time-dependent manner. 8-OHQ- and CQ-Cu, but not mixture of their analogues and Cu, could induce cancer cell death in a concentration- and time-dependent manner. Western Blot Analysis Cell Line:DCIS cellsConcentration:1,2.5,5 μM.Incubation Time:0,2,4,8,12 hours Result:Mixture of CuCl2 inhibited the CT-like activity in a concentration- and time-dependent manner. Mixture of CuCl2 decreased proteasomal activity and increased ubquititinated proteins and Bax accumulated in a time-dependent manner. RT-PCR Cell Line:Lipopolysaccharides (HY-D1056)-stimulated Raw 264.7 cells Concentration:25,50,75,100 μM Incubation Time:30 min Result:Inhibited of LPS-induced NO and iNOS expression.Inhibits transcription of iNOS. Had not affect phosphorylation of MAPKs. Inhibited NF-jB-binding activity and C/EBPb-binding activity.

Animal Model:CD1 mice Dosage:25,50,100 mg/kg Administration:Intraperitoneal injection (i.p.)Result:Resulted in a significant dose-related increase in the number of micronucleated polychromatic erythrocytes (MPCE) at the 24 h samplingtime for all doses tested. Animal Model:C57BL miceDosage:0.3% 4 times weekly.Administration:Skin administration Result:Caused depigmented hair to grow in patterns which change with time. Sufficiently frequent applications result in virtually complete depigmentation in young adult C57BL female mice, while single application causes isolated bands of depigmented hair.

Oxyquinoline | NSC 2039 | NSC-2039 | NSC2039

Others

Other Targets

Others

Other Indications

——

148-24-3

145.16

C9H7NO

>98% (HPLC)

Water: 556 mg/l at 20 °C

OC1=C2N=CC=CC2=CC=C1

8-Hydroxyquinoline

(-20℃)

With Ice Pack

≥ 2 years