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Adavivint
CAS No. 1467093-03-3
Adavivint ( SM-04690 | SM 04690 | SM04690 )
产品货号. M12002 CAS No. 1467093-03-3
Adavivint (SM-04690、SM 04690、SM04690) 是一种新型小分子 Wnt 通路抑制剂，体外 EC50 为 3 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥787 | 有现货 |
|
| 10MG | ￥1169 | 有现货 |
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| 25MG | ￥1841 | 有现货 |
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| 50MG | ￥3469 | 有现货 |
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| 100MG | ￥4824 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥877 | 有现货 |
|
生物学信息
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产品名称Adavivint
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Adavivint (SM-04690、SM 04690、SM04690) 是一种新型小分子 Wnt 通路抑制剂，体外 EC50 为 3 nM。
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产品描述Adavivint (SM-04690, SM 04690, SM04690) is a novel small molecule Wnt pathway inhibitor with EC50 of 3 nM in vitro; induces hMSC differentiation into mature, functional chondrocytes and decreases cartilage catabolic marker levels; significantly improves Osteoarthritis Research Society International (OARSI) histology scores and biomarkers in a rodent OA model.Rheumatoid Arthritis Phase 2 Clinical(In Vitro):Adavivint (SM04690) is a potent and selective inhibitor of Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCF/LEF-reporter assay in SW480 colon cancer cells, and shows no effect on SV40 luciferase reporter. Adavivint enhances aggregation of human mesenchymal stem cells (hMSCs) with an EC50 of 10 nM. Adavivint (30 nM) protects chondrocytes from catabolic breakdown in vitro.(In Vivo):Adavivint (0.3 μg) enhances cartilage repair and protection in the rat acute cruciate ligament tear and partial medial meniscectomy osteoarthritis (ACLT + pMMx OA) model.
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体外实验——
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体内实验——
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同义词SM-04690 | SM 04690 | SM04690
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通路Wnt/Notch/Hedgehog
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靶点Wnt/beta/catenin
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受体Wnt/beta/catenin
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研究领域Inflammation/Immunology
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适应症Rheumatoid Arthritis
化学信息
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CAS Number1467093-03-3
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分子量505.557
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分子式C29H24FN7O
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纯度>98% (HPLC)
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溶解度DMSO : 25 mg/mL 49.45 mM
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SMILESCC(C)CC(=O)NC1=CN=CC(=C1)C2=CC3=C(C=C2)NN=C3C4=NC5=C(N4)C=NC=C5C6=CC(=CC=C6)F
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化学全称N-(5-{3-[7-(3-fluorophenyl)-1H-imidazo[4,5-c]pyridin-2-yl]-1H-indazol-5-yl}pyridin-3-yl)-3-methylbutanamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Yazici Y, et al. Osteoarthritis Cartilage. 2017 Jul 13. pii: S1063-4584(17)31085-3.
2. Deshmukh V, et al. Osteoarthritis Cartilage. 2017 Sep 6. pii: S1063-4584(17)31167-6.
