WS-3 ( WS3 | WS 3 )

产品货号. M11759 CAS No. 1421227-52-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

WS-3
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

一种小分子，可诱导 β 细胞增殖，EC50 为 74 nM。
产品描述

A small molecule that can induce proliferation of β cells with EC50 of 74 nM; modulates the activity of Erb3 binding protein-1 and the IκB kinase pathway; can reversibly proliferates primary RPE cells isolated from fetal and adult human donors.
体外实验

WS3 induces pancreatic R7T1 β cell proliferation in dose response, with an EC50 value of 0.28 μM.WS3 (1.0 nM-1.0 μM) reversibly proliferate primary retinal pigment epithelial (RPE) cells isolated from fetal and adult human donors. Following withdrawal of WS3, RPE cells differentiate into a functional monolayer, as exhibited by their expression of mature RPE genes and phagocytosis of photoreceptor outer segments.
体内实验

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同义词

WS3 | WS 3
通路

Immunology/Inflammation
靶点

IκB kinase (IKK)
受体

ErbB3-BindingProtein-1(EBP1)|IκBkinase
研究领域

Inflammation/Immunology
适应症

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CAS Number

1421227-52-2
分子量

569.5781
分子式

C28H30F3N7O3
纯度

>98% (HPLC)
溶解度

DMSO: ≥ 43 mg/mL
SMILES

CN1CCN(CC2=CC=C(NC(NC3=CC=C(OC4=CC(NC(C5CC5)=O)=NC=N4)C=C3)=O)C=C2C(F)(F)F)CC1
化学全称

Cyclopropanecarboxamide, N-[6-[4-[[[[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-4-pyrimidinyl]-

1. Swoboda JG, et al. ACS Chem Biol. 2013 Jul 19;8(7):1407-11. 2. Shen W, et al. J Am Chem Soc. 2013 Feb 6; 135(5):1669-72.

计算器

产品手册

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