HDAC8-IN-22d ( HDAC8-IN-1 | MDK-7933 | MDK 7933 | MDK7933 )

产品货号. M11745 CAS No. 1417997-93-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

HDAC8-IN-22d
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

HDAC8-IN-22d 是一种有效的选择性 HDAC8 抑制剂，IC50 为 27.2 nM。
产品描述

HDAC8-IN-22d is a potent, selective HDAC8 inhibitor with IC50 of 27.2 nM, exhibits no activity against other HDACs and limited activity against HDAC1 and 3; shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5); exhibits cytotoxicity against human lung CL1-5 cells (IC50=7.0 uM) similar to that of SAHA yet without significant cytotoxicity for normal IMR-90 cells.
体外实验

HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. HDAC8-IN-1 (compound 22 d) shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5); HDAC8-IN-1 exhibits cytotoxicity against human lung CL1-5 cells without significant cytotoxicity for normal IMR-90 cells.
体内实验

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同义词

HDAC8-IN-1 | MDK-7933 | MDK 7933 | MDK7933
通路

Cell Cycle/DNA Damage
靶点

HDAC
受体

HDAC8
研究领域

——
适应症

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CAS Number

1417997-93-3
分子量

345.398
分子式

C22H19NO3
纯度

>98% (HPLC)
溶解度

DMSO: 130 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

ONC(/C=C/C1=CC=C(C=C1C2=CC=C(C=C2)C3=CC=CC=C3)OC)=O
化学全称

(2E)-N-Hydroxy-3-(5-methoxy[1,1':4',1''-terphenyl]-2-yl)-2-propenamide

1. Huang WJ, et al. ChemMedChem. 2012 Oct;7(10):1815-24.

计算器

产品手册

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