021-51111890
购物车（）
sales@molnova.cn
Lucerastat
CAS No. 141206-42-0
Lucerastat ( N-Butyldeoxygalactonojirimycin | ACT-434964 | OGT-923 )
产品货号. M11715 CAS No. 141206-42-0
一种半乳糖类似物，是一种 UDP-葡萄糖神经酰胺葡萄糖基转移酶 (UGCG/GCS) 抑制剂 (IC50=41.4 uM)。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥4179 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称Lucerastat
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述一种半乳糖类似物，是一种 UDP-葡萄糖神经酰胺葡萄糖基转移酶 (UGCG/GCS) 抑制剂 (IC50=41.4 uM)。
-
产品描述A galactose analogue that is an UDP-glucose ceramide glucosyltransferase (UGCG/GCS) inhibitor (IC50=41.4 uM); prevents glucosylceramide biosynthesis both in vitro and in mouse models of lysosome storage disorders, without affecting α-glucosidase I and II or β-glucocerebrosidase (IC50>1 mM); shows potential as substrate reduction therapy for glycolipid storage disorders such as Gaucher disease and Fabry disease.Other Indication Phase 1 Clinical.
-
体外实验Fabry patient-derived fibroblasts with the genotypes R301G (residual -GalA activity; 20%) R220X (<3%) and W162X (<1%). Cell Viability Assay.Cell Line:Fabry patient-derived fibroblasts with the genotypes R301G (residual-GalA activity; 20%) R220X (<3%) and W162X (<1%). Concentration:Incubation Time:9 days.Result:Dose-dependently inhibited GCS, reducing glucosylceramide and increasing sphingomyelin.
-
体内实验Lucerastat (1200 mg/kg/day food admix), a GCS inhibitor, reduces Gb3 in the absence of residual-GalA activity. Animal Model:Fabry mice (Gla-/0 and Gla-/-, n = 5 or 6 for each gender).Dosage:1200 mg/kg/day food admix.Administration:Food admix for 20 weeks.Result:Reduced lipid storage in two major organs affected by FD: mean Gb3 in the kidneys (-33%, p<0.01). and α-galactose- terminated glycosphingolipids in the dorsal root ganglia (-48%, p<0.05). In the liver of the Fabry mice, mean glucosylceramide (GlcCer (24:0)) was reduced (-59%, p<0.001) in addition to Gb3 (24:1) (-37%, p<0.05) demonstrating substrate reduction through GCS inhibition.
-
同义词N-Butyldeoxygalactonojirimycin | ACT-434964 | OGT-923
-
通路Others
-
靶点Other Targets
-
受体Other Targets
-
研究领域Other Indications
-
适应症Other Disease
化学信息
-
CAS Number141206-42-0
-
分子量219.281
-
分子式C10H21NO4
-
纯度>98% (HPLC)
-
溶解度In Vitro:?H2O : 24 mg/mL (109.45 mM)
-
SMILESO[C@H]1[C@@H](CO)N(CCCC)C[C@H](O)[C@H]1O
-
化学全称(2R,3S,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
-
Angiogenin (108-122)...
Angiogenin (108-122) TFA is an angiogenin peptide.Angiogenin (108-122) acts as a therapeutic agent for the prophylaxis and/or treatment of cancer, an infectious disease, a fibrotic disease, an inflammatory disease, a neurodegenerative disease, an autoimmune disease, or a heart and vascular disease.
-
Sanggenone H
Sanggenone H may have antiphlogistic activity, it attenuated the secretion of TNF-α± and IL-1α2 and inhibited the NF-κB nuclear translocation in LPS-stimulated macrophages.
-
Oxyphyllacinol
Oxyphyllacinol has antidiarrheal activity.Oxyphyllacinol has been shown to treat dementia. Oxyphyllacinol was isolated from the S. nodiflora water fraction, while the S. nodiflora water fraction has been shown to have antioxidant and anti-aging activities, inducing mitochondrial activity and increasing ctt1 gene expression by regulating stress tolerance response.
