CL 316243 disodium

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CL 316243 是一种有效、高选择性、口服活性 β3-肾上腺素受体激动剂，EC50 为 3 nM。

CL 316243 is a potent, highly selective, orally active β3-adrenoceptor agonist with EC50 of 3 nM; Displays >10000-fold selective over β1 and β2 receptors; Significantly increases brown adipose tissue thermogenesis and resting metabolic rate in mice, also increases the concentration of insulin receptors and decreases the levels of serum insulin and blood glucose during the glucose overloading test.Obesity Discontinued.

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Animal Model:Male C57BL/6J mice fed with high-fat diets (HFD; 45%-kcal fat) or a control diet (ND; 10%-kcal fat) for 14 weeks Dosage:0.1 mg/kg/day Administration:once a day; 1 weeks Result:Exhibited a premium effect of obesity in mice.

CL316243 disodium

GPCR/G Protein

Adrenergic Receptor

Adrenergic Receptor

Metabolic Disease

Obesity

138908-40-4

465.8

C20H18ClNNa2O7

>98% (HPLC)

In Vitro:?H2O : 20 mg/mL (42.94 mM助)

CC(CC1=CC2=C(C=C1)OC(O2)(C(=O)[O-])C(=O)[O-])NCC(C3=CC(=CC=C3)Cl)O.[Na+].[Na+]

5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylic acid disodium salt

(-20℃)

With Ice Pack

≥ 2 years