021-51111890
购物车（）
sales@molnova.cn
Alvimopan monohydrate
CAS No. 1383577-62-5
Alvimopan monohydrate ( Alvimopan monohydrate )
产品货号. M11587 CAS No. 1383577-62-5
一种选择性外周作用 μ-阿片类拮抗剂，IC50 为 1.7 nM，用于治疗术后肠梗阻。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 50MG | ￥3897 | 有现货 |
|
| 100MG | ￥5733 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称Alvimopan monohydrate
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述一种选择性外周作用 μ-阿片类拮抗剂，IC50 为 1.7 nM，用于治疗术后肠梗阻。
-
产品描述A selective peripherally acting μ-opioid antagonist with IC50 of 1.7 nM for the treatment of postoperative ileus; prevents gastrointestinal effects of intravenous morphine without affecting analgesia; orally active.Other Indication Approved.
-
体外实验Alvimopan inhibits the loperamide-stimulated [35S]GTPγS binding to membranes containing the cloned human μ-opioid receptor, with an IC50 of 1.7 nM.
-
体内实验Alvimopan (0.1-1.0 mg/kg; p.o.) partially antagonizes the slowing of small intestinal transit of 113Sn-labelled microspheres in rats.Alvimopan (3 mg/kg; p.o.) has no effect on the visceromotor behavioural responses (VMR) induced by noxious colorectal distension (CRD) in conscious rats.
-
同义词Alvimopan monohydrate
-
通路Endocrinology/Hormones
-
靶点Opioid Receptor
-
受体Opioid Receptor
-
研究领域Other Indications
-
适应症Other Disease
化学信息
-
CAS Number1383577-62-5
-
分子量442.5479
-
分子式C25H34N2O5
-
纯度>98% (HPLC)
-
溶解度10 mM in DMSO
-
SMILESC[C@H]1CN(C[C@@H](C(NCC(O)=O)=O)Cc2ccccc2)CC[C@]1(c3cc(O)ccc3)C.O
-
化学全称Glycine, N-[(2S)-2-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]-, hydrate (1:1)
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Fukuda H, et al. Brain Res. 2006 Aug 2;1102(1):63-70.
2. Taguchi A, et al. N Engl J Med. 2001 Sep 27;345(13):935-40.
3. Schmidt WK. Am J Surg. 2001 Nov;182(5A Suppl):27S-38S.
产品手册
关联产品
-
Nociceptin (1-13) am...
Nociceptin (1-13), amide 是一种强效激动剂阿片类受体样 1 (ORL1) 受体，对小鼠输精管的 pEC50 为 7.9，与大鼠前脑膜结合的 Ki 为 0.75 nM。
-
Hemorphin-7
Hemorphin-7 binds to the angiotensin IV receptor, triggering multiple effects including cellular proliferation and memory enhancement. Hemorphins are endogenous peptides belonging to the family of atypical opioid peptides released from hydrolyzed hemoglobin. Hemorphin-7 is investigated as a potential biomarker for breast cancer.
-
TAN-67 dihydrobromid...
一种有效的选择性 δ-阿片受体激动剂，对 δ1 亚型具有高亲和力和选择性，Ki 为 1.12 nM。
