M4284

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

M4284 (M-4284) 是一种高亲和力联苯甘露糖苷 FimH 抑制剂，血凝测定中的 HAI 为 16 nM。

M4284 (M-4284) is a high-affinity biphenyl mannoside FimH inhibitor with HAI of 16 nM in hemagglutination assay; reduces intestinal colonization of genetically diverse UPEC isolates, while simultaneously treating UTI, without notably disrupting the structural configuration of the gut microbiota; reduces UTI89 levels in the gut and urinary tracts of mice.

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M4284 (oral administration; 100 mg/kg; 3 doses) can reduces UTI89 levels in the gut and urinary tracts of mice that are concurrently colonized with UTI89 in the gut and bladder. And treating mice with additonal M4284 doses further reduces the UTI89 population and the number of UPEC is lower in M4284-treated mice after termination of treatment. Animal Model:C3H/HeN mice.Dosage:100 mg/kg Administration:Oral administation; a single dose.Result:Had activities against different UPEC strains in different host genetic backgrounds and gut microbial community contexts.

M-4284 | M 4284

GPCR/G Protein

Antibacterial

Antibacterial

Infection

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1373346-85-0

460.483

C23H28N2O8

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (271.46 mM)

CC1=C(C=CC(=C1)C2=CC(=CC(=C2)C(=O)NC)C(=O)NC)OC3C(C(C(C(O3)CO)O)O)O

N3,N5,3'-trimethyl-4'-(((3S,4R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-[1,1'-biphenyl]-3,5-dicarboxamide

(-20℃)

With Ice Pack

≥ 2 years