Senexin-A

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CDK8 (IC50=0.28 uM) 和 CDK19 的选择性抑制剂；抑制 CDK8 和 CDK19 ATP 位点结合，Kd50 分别为 0.83 uM 和 0.31 uM。

A selective inhibitor of CDK8 (IC50=0.28 uM) and CDK19; inhibits CDK8 and CDK19 ATP site binding with Kd50 of 0.83 uM and 0.31 uM, respectively; inhibits only p21-induced transcription but not other biological effects of p21, inhibits β-catenin-dependent transcription in HCT116 colon carcinoma cells; suppresses damage-induced tumor-promoting paracrine activities of tumor cells and normal fibroblasts and reverses the increase in tumor engraftment and serum mitogenic activity in mice pretreated with doxorubicin.

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Senexin A

Angiogenesis

CDK

CDK

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1366002-50-7

274.32

C17H14N4

>98% (HPLC)

DMSO: ≥100 mg/mL

N#CC1=CC2=C(NCCC3=CC=CC=C3)N=CN=C2C=C1

6-Quinazolinecarbonitrile, 4-[(2-phenylethyl)amino]-

(-20℃)

With Ice Pack

≥ 2 years