Phenazopyridine hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

非那吡啶盐酸盐是一种局部镇痛化合物，已用于治疗泌尿道疾病。

Phenazopyridine hydrochloride is a local analgesic that has been used in urinary tract disorders.

Cell Differentiation Assay.Cell Line:Human ES cellsConcentration:3 μM Incubation Time:6 weeks Result:After 10 weeks formed a neural network in the cells.RT-PCR.Cell Line:Human ES cells Concentration:3 μM Incubation Time:6 weeks Result:Accelerated emergence of early neuronal markers and decreased markers of undifferentiated and non-neural cells.

Animal Model:C57BL/6 mice model of Alzheimer's diseaseDosage:15 mg/kg Administration:Intraperitoneal injection (i.p.); Once daily for 2 weeks Result:Increased the RPS23RG1 levels in lungs, liver and kidneys of mice.Animal Model:APP/PS1 mice model of Alzheimer's disease Dosage:15 mg/kg Administration:Intracerebroventricularly injection; Once daily for 2 weeks Result:Significantly reduced amyloid plaques.Increased protein levels of RPS23RG1, PSD-95, and phosphorylated/inactivated GSK-3β, though without affecting levels of tau, phosphorylated tau, and p35.

Phenazopyridine Hydrochloride | Phenazopyridine HCl

Membrane Transporter/Ion Channel

Sodium Channel

Sodium Channel

Inflammation/Immunology

——

136-40-3

249.7

C11H12ClN5

>98% (HPLC)

DMSO: 50 mg/mL (200.24 mM)

C1=CC=C(C=C1)N=NC2=C(N=C(C=C2)N)N.Cl

3-phenyldiazenylpyridine-2,6-diamine;hydrochloride

(-20℃)

With Ice Pack

≥ 2 years