JNJ-42165279 ( JNJ42165279 | JNJ 42165279 )

产品货号. M11398 CAS No. 1346528-50-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

JNJ-42165279
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

JNJ-42165279 是一种高选择性脂肪酸酰胺水解酶 (FAAH) 抑制剂，对 hFAAH 的 IC50 为 70 nM。
产品描述

JNJ-42165279 is a highly selective inhibitor of fatty acid amide hydrolase (FAAH) with IC50 of 70 nM for hFAAH; no inhibition on CYPs and hERG at 10 uM; blocks FAAH in the brain and periphery of rats , causes an elevation of the concentrations of AEA, OEA, and PEA; demonstrates activity in the spinal nerve ligation (SNL) model of neuropathic pain; exhibited excellent ADME and pharmacodynamic properties.Anxiety Phase 2 Clinical.
体外实验

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体内实验

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同义词

JNJ42165279 | JNJ 42165279
通路

Metabolic Enzyme/Protease
靶点

FAAH
受体

hFAAH|rFAAH
研究领域

Neurological Disease
适应症

Anxiety

CAS Number

1346528-50-4
分子量

410.8024
分子式

C18H17ClF2N4O3
纯度

>98% (HPLC)
溶解度

10 mM in DMSO
SMILES

C1CN(CCN1CC2=CC3=C(C=C2)OC(O3)(F)F)C(=O)NC4=C(C=CN=C4)Cl
化学全称

1-Piperazinecarboxamide, N-(4-chloro-3-pyridinyl)-4-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]-

1. Keith JM, et al. ACS Med Chem Lett. 2015 Nov 2;6(12):1204-8.

计算器

产品手册

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