Zinc pyrithione

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

吡啶硫酮锌是一种抗真菌和抗菌剂，通过阻断质子泵来破坏膜运输。

Zinc pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump.(In Vitro):Zinc pyrithione is considered as a coordination complex of zinc. The pyrithione ligands, which are formally monoanions, are chelated to Zn 2+ via oxygen and sulfur centers. In the crystalline state, zinc pyrithione exists as a centrosymmetric dimer, where each zinc is bonded to two sulfur and three oxygen centers. In solution, however, the dimers dissociate via scission of one Zn-O bond. Zinc pyrithione, which is a dimer but is probably biologically active as a monomer, induces plasma membrane depolarization with half-maximal effect (K1/2) of about 0.3 mM.Zinc Pyrithione (10 nM-10 μM; 72 hours) significantly induces cell death in AAVS1 cells.

Zinc pyrithione is considered as a coordination complex of zinc. The pyrithione ligands, which are formally monoanions, are chelated to Zn 2+ via oxygen and sulfur centers. In the crystalline state, zinc pyrithione exists as a centrosymmetric dimer, where each zinc is bonded to two sulfur and three oxygen centers. In solution, however, the dimers dissociate via scission of one Zn-O bond. Zinc pyrithione, which is a dimer but is probably biologically active as a monomer, induces plasma membrane depolarization with half-maximal effect (K1/2) of about 0.3 mM. Zinc Pyrithione (10 nM-10 μM; 72 hours) significantly induces cell death in AAVS1 cells.

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AI3-62421, BC-J, Biocut ZP, Finecide ZPT, Pyrithione zinc | Zinc pyrithione

Membrane Transporter/Ion Channel

Proton Pump

Proton pump

Cardiovascular Disease

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13463-41-7

317.7

C10H8N2O2S2Zn

>98% (HPLC)

DMSO: 30 mg/mL (94.42 mM)

C1=CC2S=[Zn+2]3(S=C4C=CC=CN4[O-]3)[O-]N2C=C1

(T-4)-Bis(1-hydroxy-2(1H)-pyridinethionato-O,S)zinc

(-20℃)

With Ice Pack

≥ 2 years