021-51111890/在线客服
购物车（）
sales@molnova.cn
  • 咨询热线
    客服服务热线 13671568941/15317326293
  • 在线咨询
    963389683
  • 微信客服
    微信客服
  • 公众号
    扫码关注公众号
首页- Products - Others - Other Targets - DS-1040 tosylate

DS-1040 tosylate

CAS No. 1335138-89-0

DS-1040 tosylate ( DS 1040 | DS1040 )

产品货号. M11340 CAS No. 1335138-89-0

DS-1040 tosylate (DS1040) 是一种活化凝血酶激活纤溶抑制剂 (TAFIa) 的小分子抑制剂，对兔 TAFIa 的 IC50 为 1.7 ng/mL。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ￥898 有现货
5MG ￥1501 有现货
25MG ￥5720 有现货
50MG ￥7431 有现货
100MG ￥12330 有现货
500MG 获取报价 有现货
1G 获取报价 有现货
1 mL x 10 mM in DMSO ￥1720 有现货
产品询价 大包装询价 加入购物车

生物学信息

  • 产品名称
    DS-1040 tosylate
  • 注意事项
    本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
  • 产品简述
    DS-1040 tosylate (DS1040) 是一种活化凝血酶激活纤溶抑制剂 (TAFIa) 的小分子抑制剂，对兔 TAFIa 的 IC50 为 1.7 ng/mL。
  • 产品描述
    DS-1040 tosylate (DS1040)?is a small molecule inhibitor of the activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC50 of 1.7 ng/mL for rabbit TAFIa; a novel fibrinolysis-enhancing agent has favorable pharmacokinetic/pharmacodynamic properties and a favorable safety profile.Stroke Phase 2 Clinical.
  • 体外实验
    DS-1040 Tosylate inhibits human carboxypeptidase N (CPN) in vitro with an IC50 of 3.02 mM.
  • 体内实验
    DS-1040 Tosylate (0.0005-0.5 mg/kg; IV) significantly reduces the microthrombi index at doses of 0.005 mg/kg and greater. DS1040 (0.016, 0.031, 0.063, 0.13, 0.25, 0.50 mg/kg; i.v.) increases plasma D-dimer levels in a dose-dependent manner in the microthrombosis model. ED50 and EDmax are 122 and 221 nmol/L, respectively. DS-1040 (0.25, 0.5, 1, 2, 4, 8, 16 mg/kg; orally) also increases plasma D-dimer levels. EC50 and ECmax values are 114 and 231 nmol/L, respectively. Animal Model:Male Slc:Wistar rats Dosage:0.0005, 0.005, 0.05, 0.5 mg/kg Administration:IV Result:Significantly reduced the microthrombi index at doses of 0.005 mg/kg and greater.
  • 同义词
    DS 1040 | DS1040
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Other Targets
  • 研究领域
    Neurological Disease
  • 适应症
    Stroke

化学信息

  • CAS Number
    1335138-89-0
  • 分子量
    465.609
  • 分子式
    C23H35N3O5S
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?DMSO : 100 mg/mL (214.77 mM)
  • SMILES
    CC1CCC(CC1)N2C=C(N=C2)CC(CCCN)C(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O
  • 化学全称
    (S)-5-amino-2-((1-((1r,4S)-4-methylcyclohexyl)-1H-imidazol-4-yl)methyl)pentanoic acid compound with 4-methylbenzenesulfonic acid (1:1)

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Zhou J, et al. J Thromb Haemost. 2017 May;15(5):961-971. 2. Gurewich V, et al. J Thromb Haemost. 2017 Oct;15(10):2080-2081. 3. Paul A Lapchak, et al. Abstract WP282: DS-1040 an Inhibitor of the Activated Thrombin Activatable Fibrinolysis Inhibitor Improves Behavior in Embolized Rabbits, Stroke. 2016;47:AWP282.
计算器

浓度计算器

摩尔计算器

分子量计算器

产品手册
关联产品

  • LL - 37, reverse seq...

    LL - 37, reverse sequence

  • Amylin, amide, human

    Amylin, a 37-amino acid polypeptide that is structurally related to calcitonin, is secreted from the B cells of the pancreas. Amylin has anoretic effects in rats. Amylin may be responsible for the etiology of insulin resistance of type II diabetes mellitus through its modulation of peripheral effects of insulin.

  • 4-Methoxycinnamyl al...

    4-Methoxycinnamyl alcohol showed toxicity to MCF-7, HeLa and DU145 cancer cell lines with IC50 values of 14.24, 7.82 and 22.10 μg/mL, respectively. 4-Methoxycinnamyl alcohol was isolated from Foeniculum vulgare. 4-Methoxycinnamyl alcohol did not show apoptotic effects but showed necrosis after 48 h in a 10 μg/mL DNA fragmentation study.

登录 注册