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A-68930 hydrochloride
CAS No. 130465-39-3
A-68930 hydrochloride ( A68930 )
产品货号. M11221 CAS No. 130465-39-3
A-68930 是一种有效、特异性、口服生物可利用的 D1 多巴胺受体激动剂，EC50 为 2.5 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 10MG | ￥4722 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称A-68930 hydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A-68930 是一种有效、特异性、口服生物可利用的 D1 多巴胺受体激动剂，EC50 为 2.5 nM。
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产品描述A-68930 is a potent, specific, orally bioavailable agonist of the D1 Dopamine receptor with EC50 of 2.5 nM; shows a much weaker agonist (EC50=3,920 nM) at the D2 dopamine receptor; demonstrates antidepressant and anorectic effects in animal models without stimulant effects.Heart Failure Discontinued.
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体外实验A68930 hydrochloride (1 μM; 5-60 minutes; 16HBE14o- or NCI-H292 cells) significantly increases phosphorylation of cAMP response element binding (CREB) protein.A68930 hydrochloride (1 μM; 48 hours; NCI-H292 cells) induces MUC5AC mRNA expression and increases the mRNA data of MUC5AC and MUC5AC protein expression.A68930 hydrochloride (1 μM; 20 minutes; NCI-H292 cells) significantly increases intracellular cAMP levels. Western Blot Analysis Cell Line:16HBE14o- or NCI-H292 cells Concentration:1 μM Incubation Time:5~60 minutes Result:Significantly increased phosphorylation of CREB.RT-PCR Cell Line:NCI-H292 cells Concentration:1 μM Incubation Time:48 hours Result:Induced MUC5AC mRNA expression.Immunofluorescence Cell Line:NCI-H292 cells Concentration:1 μM Incubation Time:48 hours Result:The mRNA data of MUC5AC, MUC5AC protein expression were increased.
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体内实验——
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同义词A68930
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通路GPCR/G Protein
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靶点Dopamine Receptor
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受体Dopamine Receptor
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研究领域Neurological Disease
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适应症——
化学信息
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CAS Number130465-39-3
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分子量307.77
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分子式C16H17NO3 · HCl
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纯度>98% (HPLC)
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溶解度——
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SMILESC1C(OC(C2=C1C(=C(C=C2)O)O)CN)C3=CC=CC=C3.Cl
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化学全称1H-2-Benzopyran-5,6-diol, 1-(aminomethyl)-3,4-dihydro-3-phenyl-, hydrochloride, (1R,3S)-rel- (9CI)
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Kebabian JW, et al. Am J Hypertens. 1990 Jun;3(6 Pt 2):40S-42S.
2. Trampus M, et al. Eur J Pharmacol. 1993 Apr 22;235(1):83-7.
3. AI-Naser HA, et al. Behav Pharmacol. 1994 Apr;5(2):210-218.
产品手册
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