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PQ-912
CAS No. 1276021-65-8
PQ-912 ( PQ 912 | PQ912 )
产品货号. M11147 CAS No. 1276021-65-8
PQ-912 (PQ 912, PQ912) 是一种有效的谷氨酰胺酰环化酶 (QC) 抑制剂，可抑制人类、大鼠和小鼠 QC，Ki 为 20-65 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称PQ-912
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述PQ-912 (PQ 912, PQ912) 是一种有效的谷氨酰胺酰环化酶 (QC) 抑制剂，可抑制人类、大鼠和小鼠 QC，Ki 为 20-65 nM。
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产品描述PQ-912 (PQ 912, PQ912)?is a potent glutaminyl cyclase (QC) inhibitor that inhibits human, rat, and mouse QC with Ki of 20-65 nM; shows a favourable profile of the compound for QC engagement coupled to a reduction of pE-Aβ and behavioural improvementsthe first in class inhibitor of glutaminyl cyclases currently being in clinical development for Alzheimer's disease.Alzheimer Disease Phase 2 Clinical.
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体外实验——
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体内实验——
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同义词PQ 912 | PQ912
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通路Others
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靶点Other Targets
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受体Other Targets
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研究领域Neurological Disease
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适应症Alzheimer Disease
化学信息
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CAS Number1276021-65-8
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分子量336.395
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分子式C19H20N4O2
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纯度>98% (HPLC)
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溶解度DMSO : 200 mg/mL 594.55 mM
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SMILESO=C1NC[C@H](C2=CC=C(OCCC)C=C2)N1C3=CC=C4C(NC=N4)=C3
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化学全称(S)-1-(1H-benzo[d]imidazol-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Hoffmann T, et al. J Pharmacol Exp Ther. 2017 Jul;362(1):119-130.
产品手册
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