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Ganaplacide

CAS No. 1261113-96-5

Ganaplacide ( KAF156 | GNF-156 )

产品货号. M11081 CAS No. 1261113-96-5

Ganaplacide (KAF156, GNF-156) 是一种新型抗疟临床候选化合物,对恶性疟原虫化合物敏感和耐药菌株具有杀血液裂殖活性,IC50 为 6-17.4 nM。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
25MG ¥13950 有现货
50MG ¥18414 有现货
100MG ¥22950 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Ganaplacide
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Ganaplacide (KAF156, GNF-156) 是一种新型抗疟临床候选化合物,对恶性疟原虫化合物敏感和耐药菌株具有杀血液裂殖活性,IC50 为 6-17.4 nM。
  • 产品描述
    Ganaplacide (KAF156, GNF-156)?is a novel antimalarial clinical candidate that shows blood schizonticidal activity with IC50 of 6-17.4 nM against P falciparum drug-sensitive and drug-resistant strains; demonstrates potent therapeutic activity in mouse models of malaria with 50, 90, and 99% effective doses of 0.6, 0.9, and 1.4 mg/kg, respectively; KAF156 is completely protective as a single oral dose of 10 mg/kg in sporozoite challenge mouse model; shows the potential to treat, prevent, and block the transmission of malaria.Parasite Infection Phase 2 Clinical.
  • 体外实验
    ——
  • 体内实验
    Animal Model:Mice (causal prophylactic rodent malaria model)Dosage:1-15 mg/kg Administration:p.o.Result:A single oral dose of 10 mg of KAF156/kg administered 2 h before infection was fully protective.
  • 同义词
    KAF156 | GNF-156
  • 通路
    Microbiology/Virology
  • 靶点
    Parasite
  • 受体
    Parasite
  • 研究领域
    Infection
  • 适应症
    Parasite Infection

化学信息

  • CAS Number
    1261113-96-5
  • 分子量
    411.457
  • 分子式
    C22H23F2N5O
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    CC1(C)C2=NC(C3=CC=C(F)C=C3)=C(NC4=CC=C(F)C=C4)N2CCN1C(CN)=O
  • 化学全称
    2-amino-1-[3-(4-fluoroanilino)-2-(4-fluorophenyl)-8,8-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl]ethan-1-one

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Kuhen KL, et al. Antimicrob Agents Chemother. 2014 Sep;58(9):5060-7. 2. Leong FJ, et al. Antimicrob Agents Chemother. 2014 Nov;58(11):6437-43. 3. Lim MY, et al. Nat Microbiol. 2016 Sep 19:16166. 4. White NJ, et al. N Engl J Med. 2016 Sep 22;375(12):1152-60.
产品手册
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