Ganaplacide
CAS No. 1261113-96-5
Ganaplacide ( KAF156 | GNF-156 )
产品货号. M11081 CAS No. 1261113-96-5
Ganaplacide (KAF156, GNF-156) 是一种新型抗疟临床候选化合物,对恶性疟原虫化合物敏感和耐药菌株具有杀血液裂殖活性,IC50 为 6-17.4 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 25MG | ¥13950 | 有现货 |
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| 50MG | ¥18414 | 有现货 |
|
| 100MG | ¥22950 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Ganaplacide
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Ganaplacide (KAF156, GNF-156) 是一种新型抗疟临床候选化合物,对恶性疟原虫化合物敏感和耐药菌株具有杀血液裂殖活性,IC50 为 6-17.4 nM。
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产品描述Ganaplacide (KAF156, GNF-156)?is a novel antimalarial clinical candidate that shows blood schizonticidal activity with IC50 of 6-17.4 nM against P falciparum drug-sensitive and drug-resistant strains; demonstrates potent therapeutic activity in mouse models of malaria with 50, 90, and 99% effective doses of 0.6, 0.9, and 1.4 mg/kg, respectively; KAF156 is completely protective as a single oral dose of 10 mg/kg in sporozoite challenge mouse model; shows the potential to treat, prevent, and block the transmission of malaria.Parasite Infection Phase 2 Clinical.
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体外实验——
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体内实验Animal Model:Mice (causal prophylactic rodent malaria model)Dosage:1-15 mg/kg Administration:p.o.Result:A single oral dose of 10 mg of KAF156/kg administered 2 h before infection was fully protective.
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同义词KAF156 | GNF-156
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通路Microbiology/Virology
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靶点Parasite
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受体Parasite
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研究领域Infection
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适应症Parasite Infection
化学信息
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CAS Number1261113-96-5
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分子量411.457
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分子式C22H23F2N5O
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纯度>98% (HPLC)
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溶解度——
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SMILESCC1(C)C2=NC(C3=CC=C(F)C=C3)=C(NC4=CC=C(F)C=C4)N2CCN1C(CN)=O
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化学全称2-amino-1-[3-(4-fluoroanilino)-2-(4-fluorophenyl)-8,8-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl]ethan-1-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
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2-Hydroxy-3,4-dimeth...
2'-Hydroxy-3,4-dimethoxychalcone, a chalcone compound isolated from the roots of Sophora japonica, has antioxidant activity and inhibited the intracellular survival of Lactobacillus donovani Parasite EC.50 Values ranged between 0.39 and 0.41 μg/mL, which can be used in the study of diabetes, treatment of schistosomiasis, malaria and other infections.
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Fervenulin
Fervenulin 是从杀线虫放线菌 Streptomyces sp. 中分离出来的。 CMU-MH021具有杀线虫活性。
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Rufigallol
Rufigallol (AI3-00865) is an electron-deficient disk-shaped molecule with six hydroxyl groups and is a good unit for inducing the formation of DLC from non-planar AIE molecules, an anthraquinone derivative.Rufigallol induces the acquisition of DLC properties, while the introduction of TPE groups gives the molecular structure good fluorescence in the aggregated state.The remarkable synergistic in vitro antimalarial effect, in vivo with vitamin C and ketones was synergistic and showed antimalarial activity.
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