HA-130

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种有效的选择性自分泌运动因子抑制剂，IC50 为 28 nM。

A potent and selective inhibitor of autotaxin with IC50 of 28 nM; shows no effect on chymotryptic, caspase, and tryptic activities of the proteasome, alkaline phosphatase and a broad-spectrum PEDs (IC50>10 uM); inhibits ATX-driven melanoma cell migration and decreases circulating LPA levels in mice.

HA130 completely blocks the ability of ATX to promote TEM (transendothelial migration). HA130 at 0.3 μM completely ablates the activity of ATX on TK1 uropod formation.

HA130 slows T cell migration across lymph node HEVs. HA130 decreases the "outside HEVs/inside HEVs" ratio by 3-4-fold compared to vehicle-treated animals vehicle.The s.c. administration of HA130 induces marked lymphocyte accumulation within the endothelial cell (EC) and sub-EC layers of HEVs in draining lymph nodes (LNs).

HA130 | HA 130

Wnt/Notch/Hedgehog

Autotaxin

ATX(autotaxin)

Cancer

——

1229652-21-4

463.2858

C24H19BFNO5S

>98% (HPLC)

DMSO: ≥ 39 mg/mL

OB(C1=CC=CC(COC2=CC=C(/C=C(SC(N3CC4=CC=C(F)C=C4)=O)/C3=O)C=C2)=C1)O

Boronic acid, B-[3-[[4-[[3-[(4-fluorophenyl)methyl]-2,4-dioxo-5-thiazolidinylidene]methyl]phenoxy]methyl]phenyl]-

(-20℃)

With Ice Pack

≥ 2 years